Unveiling post-MIS-N cardiomyopathy by longitudinal multimodality global cardiac assessment from neonatal insult to 16-month follow-up.

IF 0.9 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Annals of Pediatric Cardiology Pub Date : 2023-11-01 Epub Date: 2024-04-23 DOI:10.4103/apc.apc_114_23
Maitri Chaudhuri, Munesh Tomar, Balasubramanyam Shankar
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Abstract

A full-term male neonate presented on the 11th day of life with late-onset multisystem inflammatory syndrome-neonate (MIS-N) (cardioneurological compromise). Immediate anti-inflammatory modulation led to a gradual recovery of neurological and coronary lesions. However, temporal evaluation unmasked silent myocardial dysfunction in echocardiography validated further by elevated biomarkers, myocardial fibrosis in cardiac magnetic resonance imaging, and abnormal strain study persisting till 16 months of follow-up. This revealed a hitherto unknown and rare progression of MIS-N into dilated cardiomyopathy.

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通过从新生儿受损伤到 16 个月随访的纵向多模态整体心脏评估,揭示 MIS-N 后心肌病。
一名足月男新生儿在出生后第 11 天出现晚期多系统炎症综合征-新生儿(MIS-N)(心脏神经系统受损)。立即进行抗炎治疗后,神经和冠状动脉病变逐渐恢复。然而,时间评估揭示了超声心动图中无声的心肌功能障碍,生物标志物的升高、心脏磁共振成像中的心肌纤维化和异常应变研究进一步证实了这一点,并一直持续到 16 个月的随访。这揭示了 MIS-N 向扩张型心肌病发展的迄今未知的罕见情况。
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来源期刊
Annals of Pediatric Cardiology
Annals of Pediatric Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
1.40
自引率
14.30%
发文量
51
审稿时长
23 weeks
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