Comparative analysis of immunological changes following realgar and arsenic trioxide treatments in a murine model of myelodysplastic syndrome.

IF 2.9 4区医学 Q3 IMMUNOLOGY Immunopharmacology and Immunotoxicology Pub Date : 2024-06-01 Epub Date: 2024-05-30 DOI:10.1080/08923973.2024.2344158

Yuchen Tao, Tingting Xue, Xiaodong Li, Runjie Guo, Yanlu Wang, Hao Xu, Kexin Hu, Xiaojie Dong, Dongqin Wang, Jianye Ren, Yu Guan, Jiahui Lu

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Abstract

Background: Myelodysplastic syndrome (MDS) is a prevalent hematological neoplastic disorder in clinics and its immunopathogenesis has garnered growing interest. Oral and intravenous arsenic agents have long been used to treat hematological malignancies. The main component of oral arsenic is realgar (arsenic disulfide), while arsenic trioxide is the main component of intravenous arsenic.

Methods: This study aimed to assess the effects of ATO and Realgar on the enhancement of peripheral blood, drug safety, and T cell immune status in the NUP98-HOXD13 (NHD13) mice model of MDS, specifically in the peripheral blood, spleen, and liver.

Results: The study findings indicate that realgar and arsenic trioxide (ATO) can improve peripheral hemogram in mice, whereas realgar promotes higher peripheral blood cell production than ATO. Furthermore, the clinical administration method and dose did not cause significant toxicity or side effects and thus can be considered safe. Coexistence and interconversion of hyperimmune function and immunosuppression in mice were also observed in this study. In addition, there were interactions between immune cells in the peripheral blood, spleen, and liver to regulate the immune balance of the body and activate immunity via T-cell activation.

Conclusion: In summary, oral and intravenous arsenic agents are beneficial in improving peripheral hemogram and immunity in mice.

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在骨髓增生异常综合征小鼠模型中对比分析雷公藤和三氧化二砷治疗后的免疫学变化。

背景：骨髓增生异常综合征（MDS）是临床上常见的血液肿瘤性疾病，其免疫发病机制日益受到关注。长期以来，口服和静脉注射砷制剂一直被用于治疗血液恶性肿瘤。口服砷剂的主要成分是雄黄（二硫化砷），而静脉注射砷剂的主要成分是三氧化二砷：本研究旨在评估 ATO 和 Realgar 对 NUP98-HOXD13 (NHD13) MDS 模型小鼠外周血、药物安全性和 T 细胞免疫状态的增强作用，特别是对外周血、脾脏和肝脏的影响：研究结果表明，雄黄和三氧化二砷（ATO）都能改善小鼠外周血象，而雄黄促进外周血细胞生成的作用高于三氧化二砷。此外，临床给药方法和剂量不会引起明显的毒性或副作用，因此可以认为是安全的。本研究还观察到小鼠免疫功能亢进和免疫抑制的共存和相互转化。此外，外周血、脾脏和肝脏中的免疫细胞之间也存在相互作用，以调节机体的免疫平衡，并通过 T 细胞活化激活免疫：总之，口服和静脉注射砷制剂有利于改善小鼠的外周血象和免疫力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunopharmacology and Immunotoxicology 医学-毒理学

CiteScore

5.40

自引率

0.00%

发文量

133

审稿时长

4-8 weeks

期刊介绍： The journal Immunopharmacology and Immunotoxicology is devoted to pre-clinical and clinical drug discovery and development targeting the immune system. Research related to the immunoregulatory effects of various compounds, including small-molecule drugs and biologics, on immunocompetent cells and immune responses, as well as the immunotoxicity exerted by xenobiotics and drugs. Only research that describe the mechanisms of specific compounds (not extracts) is of interest to the journal. The journal will prioritise preclinical and clinical studies on immunotherapy of disorders such as chronic inflammation, allergy, autoimmunity, cancer etc. The effects of small-drugs, vaccines and biologics against central immunological targets as well as cell-based therapy, including dendritic cell therapy, T cell adoptive transfer and stem cell therapy, are topics of particular interest. Publications pointing towards potential new drug targets within the immune system or novel technology for immunopharmacological drug development are also welcome. With an immunoscience focus on drug development, immunotherapy and toxicology, the journal will cover areas such as infection, allergy, inflammation, tumor immunology, degenerative disorders, immunodeficiencies, neurology, atherosclerosis and more. Immunopharmacology and Immunotoxicology will accept original manuscripts, brief communications, commentaries, mini-reviews, reviews, clinical trials and clinical cases, on the condition that the results reported are based on original, clinical, or basic research that has not been published elsewhere in any journal in any language (except in abstract form relating to paper communicated to scientific meetings and symposiums).