Optimal body mass index for protecting middle-aged and elderly patients with fatty liver from future fractures.

IF 2.6 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Endocrine Connections Pub Date : 2024-05-01 DOI:10.1530/EC-24-0089

Hsiao-Yun Yeh, Hung-Ta Hondar Wu, Hsiao-Chin Shen, Tzu-Hao Li, Ying-Ying Yang, Kuei-Chuan Lee, Yi-Hsuan Lin, Chia-Chang Huang, Ming-Chih Hou

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Abstract

Objective: Previous studies have suggested that body mass index (BMI) should be considered when assessing the relationship between fatty liver (FL) and osteoporosis. The aim of this study was to investigate future fracture events in people with FL, focusing on the effect of BMI in both sexes.

Methods: This retrospective cohort study from 2011 to 2019 enrolled 941 people, including 441 women and 500 men, aged 50 years or older who underwent liver imaging (ultrasound, computed tomography, or magnetic resonance image) and dual-energy X-ray absorptiometry (DXA, for bone mineral density measurements). The study examined predictors of osteoporosis in both sexes, and the effect of different ranges of BMI (18.5-24, 24-27, and ≥27 kg/m2 in women; 18.5-24, 24-27, 27-30 and ≥30 kg/m2 in men) on the risk of future fractures in FL patients.

Results: The average follow-up period was 5.3 years for women and 4.2 years for men. Multivariate analysis identified age and BMI as independent risk factors for osteoporosis in both sexes. Each unit increase in BMI decreased the risk of osteoporosis by ≥10%. In both women and men with FL, a BMI of 24-27 kg/m2 offered protection against future fractures, compared to those without FL and with a BMI of 18.5-24 kg/m2.

Conclusion: The protective effect of a higher BMI against future fractures in middle-aged and elderly women and men with FL is not uniform and decreases beyond certain BMI ranges.

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保护中老年脂肪肝患者避免未来骨折的最佳体重指数。

研究目的以往的研究表明，在评估脂肪肝（FL）与骨质疏松症之间的关系时，应考虑体重指数（BMI）。本研究旨在调查脂肪肝患者未来的骨折事件，重点关注体重指数对男女患者的影响：这项从 2011 年到 2019 年的回顾性队列研究共招募了 941 人，包括 441 名女性和 500 名男性，年龄均在 50 岁或以上，他们都接受了肝脏成像（超声波、计算机断层扫描或磁共振成像）和双能 X 射线吸收测量（DXA，用于测量骨矿密度）。该研究探讨了男女骨质疏松症的预测因素，以及不同范围的体重指数（女性为 18.5-24、24-27 和≥27 kg/m2；男性为 18.5-24、24-27、27-30 和≥30 kg/m2）对 FL 患者未来骨折风险的影响：女性平均随访 5.3 年，男性平均随访 4.2 年。多变量分析发现，年龄和体重指数是男女骨质疏松症的独立风险因素。体重指数每增加一个单位，骨质疏松症的风险就会降低≥10%。在患有 FL 的女性和男性中，与没有 FL 且 BMI 为 18.5-24 kg/m2 的人相比，BMI 为 24-27 kg/m2 的人可防止未来发生骨折：结论：较高的体重指数对患有 FL 的中老年女性和男性未来骨折的保护作用并不一致，超过一定的体重指数范围后，保护作用就会减弱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Connections Medicine-Internal Medicine

CiteScore

5.00

自引率

3.40%

发文量

361

审稿时长

6 weeks

期刊介绍： Endocrine Connections publishes original quality research and reviews in all areas of endocrinology, including papers that deal with non-classical tissues as source or targets of hormones and endocrine papers that have relevance to endocrine-related and intersecting disciplines and the wider biomedical community.