Human umbilical cord mesenchymal stem cells combined with porcine small intestinal submucosa promote the healing of full-thickness skin injury in SD rats.

IF 2.4 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Future Science OA Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI:10.2144/fsoa-2023-0123

Xu XiaoMing, Chen Yan, Gu JiaMing, Liang LiTao, Zhang LiJuan, Song Ying, Yuan Lu, Song Qian, Dong Jian

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Abstract

Aim: To assess the therapeutic potential of human umbilical cord mesenchymal stem cells (hUCMSCs) combined with porcine small intestinal submucosa (SIS) on full-thickness skin injuries in rats. Methods: We established full-thickness skin injury models in Sprague-Dawley rats, dividing them into blank control, SIS, hUCMSCs and hUCMSCs combined with SIS. We monitored wound healing, scores and area, and analyzed inflammatory cells, microvessel density and collagen fibers after 12 days. Results: The blank group showed no healing, forming a scar of 0.6 × 0.5 cm², while SIS and hUCMSCs groups exhibited incomplete healing with 0.4 × 0.5 cm² scabs. Wound healing was significantly better in the hUCMSCs combined with the SIS group. Conclusion: Local application of hUCMSCs combined with SIS enhances full-thickness skin injury wound healing in rats.

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人脐带间充质干细胞与猪小肠粘膜下层结合可促进 SD 大鼠全厚皮肤损伤的愈合。

目的：评估人脐带间充质干细胞（hUCMSCs）与猪小肠粘膜（SIS）结合对大鼠全厚皮肤损伤的治疗潜力。方法我们建立了 Sprague-Dawley 大鼠全厚皮肤损伤模型，将其分为空白对照组、SIS 组、hUCMSCs 组和 hUCMSCs 与 SIS 结合组。12 天后监测伤口愈合、评分和面积，并分析炎症细胞、微血管密度和胶原纤维。结果显示空白组伤口未愈合，形成 0.6 × 0.5 平方厘米的疤痕，而 SIS 组和 hUCMSCs 组伤口愈合不完全，结痂面积为 0.4 × 0.5 平方厘米。hUCMSCs 与 SIS 组的伤口愈合明显更好。结论局部应用 hUCMSCs 与 SIS 可促进大鼠全厚皮肤损伤伤口的愈合。

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来源期刊

Future Science OA MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.00

自引率

4.00%

发文量

审稿时长

13 weeks

期刊介绍： Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries