Why and How to Integrate Early Palliative Care Into Cutting-Edge Personalized Cancer Care.

Laura A Petrillo, Katie Fitzgerald Jones, Areej El-Jawahri, Justin Sanders, Joseph A Greer, Jennifer S Temel
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Abstract

Early palliative care, palliative care integrated with oncology care early in the course of illness, has myriad benefits for patients and their caregivers, including improved quality of life, reduced physical and psychological symptom burden, enhanced prognostic awareness, and reduced health care utilization at the end of life. Although ASCO and others recommend early palliative care for all patients with advanced cancer, widespread implementation of early palliative care has not been realized because of barriers such as insufficient reimbursement and a palliative care workforce shortage. Investigators have recently tested several implementation strategies to overcome these barriers, including triggers for palliative care consultations, telehealth delivery, navigator-delivered interventions, and primary palliative care interventions. More research is needed to identify mechanisms to distribute palliative care optimally and equitably. Simultaneously, the transformation of the oncology treatment landscape has led to shifts in the supportive care needs of patients and caregivers, who may experience longer, uncertain trajectories of cancer. Now, palliative care also plays a clear role in the care of patients with hematologic malignancies and may be beneficial for patients undergoing phase I clinical trials and their caregivers. Further research and clinical guidance regarding how to balance the risks and benefits of opioid therapy and safely manage cancer-related pain across this wide range of settings are urgently needed. The strengths of early palliative care in supporting patients' and caregivers' coping and centering decisions on their goals and values remain valuable in the care of patients receiving cutting-edge personalized cancer care.

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为什么以及如何将早期姑息治疗纳入最前沿的个性化癌症护理中?
早期姑息关怀,即在病程早期将姑息关怀与肿瘤治疗相结合,对患者及其照护者有诸多益处,包括改善生活质量、减轻生理和心理症状负担、提高预后意识以及减少生命末期医疗服务的使用。尽管 ASCO 和其他机构建议对所有晚期癌症患者实施早期姑息治疗,但由于报销不足和姑息治疗人才短缺等障碍,早期姑息治疗尚未得到广泛实施。研究人员最近测试了几种克服这些障碍的实施策略,包括姑息关怀会诊触发器、远程医疗服务、导航员提供的干预措施以及初级姑息关怀干预措施。还需要更多的研究来确定以最佳方式公平分配姑息关怀的机制。与此同时,肿瘤治疗格局的转变也导致了患者和照护者对支持性照护需求的变化,他们可能会经历更长的、不确定的癌症轨迹。现在,姑息治疗在血液系统恶性肿瘤患者的护理中也发挥着明确的作用,并可能对接受一期临床试验的患者及其护理人员有益。如何在阿片类药物治疗的风险和益处之间取得平衡,并在这种广泛的情况下安全地管理癌症相关疼痛,亟需进一步的研究和临床指导。早期姑息治疗在支持患者和照护者应对问题以及根据他们的目标和价值观做出决定方面的优势,在照护接受最先进的个性化癌症治疗的患者方面仍然很有价值。
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期刊介绍: The Ed Book is a National Library of Medicine–indexed collection of articles written by ASCO Annual Meeting faculty and invited leaders in oncology. Ed Book was launched in 1985 to highlight standards of care and inspire future therapeutic possibilities in oncology. Published annually, each volume highlights the most compelling research and developments across the multidisciplinary fields of oncology and serves as an enduring scholarly resource for all members of the cancer care team long after the Meeting concludes. These articles address issues in the following areas, among others: Immuno-oncology, Surgical, radiation, and medical oncology, Clinical informatics and quality of care, Global health, Survivorship.
期刊最新文献
Cell-Based Therapies in GI Cancers: Current Landscape and Future Directions. Integrative Oncology: Incorporating Evidence-Based Approaches for Patients With GI Cancers. Erratum: Integrating Palliative Care and Hematologic Malignancies: Bridging the Gaps for Our Patients and Their Caregivers. Curing Stage IV Melanoma: Where Have We Been and Where Are We? State-Of-The-Art Advancements on Cancer Vaccines and Biomarkers.
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