Dysfunctional intestinal microvascular endothelial cells: Insights and therapeutic implications in gastrointestinal inflammation.

Immunometabolism (Cobham (Surrey, England)) Pub Date : 2024-05-29 eCollection Date: 2024-04-01 DOI:10.1097/IN9.0000000000000043
Ji Seok Park, Gail A M Cresci
{"title":"Dysfunctional intestinal microvascular endothelial cells: Insights and therapeutic implications in gastrointestinal inflammation.","authors":"Ji Seok Park, Gail A M Cresci","doi":"10.1097/IN9.0000000000000043","DOIUrl":null,"url":null,"abstract":"<p><p>The intestinal microvascular endothelium plays a crucial role in orchestrating host responses to inflammation within the gastrointestinal tract. This review delves into the unique aspects of intestinal microvascular endothelial cells, distinct from those of larger vessels, in mediating leukocyte recruitment, maintaining barrier integrity, and regulating angiogenesis during inflammation. Specifically, their role in the pathogenesis of inflammatory bowel diseases, where dysregulated endothelial functions contribute to the disease progression, is reviewed. Furthermore, this review discusses the isolation technique for these cells and commonly used adhesion molecules for in vitro and in vivo experiments. In addition, we reviewed the development and therapeutic implications of a biologic agent targeting the interaction between α<sub>4</sub>β<sub>7</sub> integrin on T lymphocytes and mucosal addressin cellular adhesion molecule-1 on gut endothelium. Notably, vedolizumab, a humanized monoclonal antibody against α<sub>4</sub>β<sub>7</sub> integrin, has shown promising outcomes in inflammatory bowel diseases and other gastrointestinal inflammatory conditions, including chronic pouchitis, immune checkpoint inhibitor-induced colitis, and acute cellular rejection post-intestinal transplantation.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"6 2","pages":"e00043"},"PeriodicalIF":0.0000,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136270/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunometabolism (Cobham (Surrey, England))","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/IN9.0000000000000043","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

The intestinal microvascular endothelium plays a crucial role in orchestrating host responses to inflammation within the gastrointestinal tract. This review delves into the unique aspects of intestinal microvascular endothelial cells, distinct from those of larger vessels, in mediating leukocyte recruitment, maintaining barrier integrity, and regulating angiogenesis during inflammation. Specifically, their role in the pathogenesis of inflammatory bowel diseases, where dysregulated endothelial functions contribute to the disease progression, is reviewed. Furthermore, this review discusses the isolation technique for these cells and commonly used adhesion molecules for in vitro and in vivo experiments. In addition, we reviewed the development and therapeutic implications of a biologic agent targeting the interaction between α4β7 integrin on T lymphocytes and mucosal addressin cellular adhesion molecule-1 on gut endothelium. Notably, vedolizumab, a humanized monoclonal antibody against α4β7 integrin, has shown promising outcomes in inflammatory bowel diseases and other gastrointestinal inflammatory conditions, including chronic pouchitis, immune checkpoint inhibitor-induced colitis, and acute cellular rejection post-intestinal transplantation.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
功能失调的肠道微血管内皮细胞:胃肠道炎症的启示和治疗意义。
肠道微血管内皮细胞在协调宿主对胃肠道炎症的反应方面发挥着至关重要的作用。这篇综述深入探讨了肠道微血管内皮细胞在炎症期间介导白细胞招募、维持屏障完整性和调节血管生成方面的独特之处,它们与大血管内皮细胞不同。具体而言,本研究综述了它们在炎症性肠病发病机制中的作用,其中内皮功能失调导致了疾病的进展。此外,本综述还讨论了这些细胞的分离技术以及用于体外和体内实验的常用粘附分子。此外,我们还综述了针对 T 淋巴细胞上的α4β7 整合素与肠道内皮细胞上的粘膜地址素细胞粘附分子-1 之间相互作用的生物制剂的开发和治疗意义。值得注意的是,vedolizumab 是一种针对 α4β7 整合素的人源化单克隆抗体,在炎症性肠病和其他胃肠道炎症(包括慢性肠袋炎、免疫检查点抑制剂诱导的结肠炎和肠道移植后的急性细胞排斥反应)方面显示出良好的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
1.10
自引率
0.00%
发文量
0
期刊最新文献
La dolce vita: fueling chimeric antigen receptor (CAR) T cells with Glut1 to improve therapeutic efficacy. Navigating a complex dance: the interplay between RNA-binding proteins and T cells in oral epithelial plasticity. Revealing the dance of NLRP3: spatiotemporal patterns in inflammasome activation. Evaluating diurnal rhythms of host responses to enteric norovirus infection in mouse models. Immunometabolic effects of β-carotene and vitamin A in atherogenesis.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1