Quantitative Proteomics for Translational Pharmacology and Precision Medicine: State of The Art and Future Outlook.

IF 4.4 3区医学 Q1 PHARMACOLOGY & PHARMACY Drug Metabolism and Disposition Pub Date : 2024-10-16 DOI:10.1124/dmd.124.001600

Bhagwat Prasad, Zubida M Al-Majdoub, Christine Wegler, Amin Rostami-Hodjegan, Brahim Achour

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Abstract

Over the past 20 years, quantitative proteomics has contributed a wealth of protein expression data, which are currently used for a variety of systems pharmacology applications, as a complement or a surrogate for activity of the corresponding proteins. A symposium at the 25th North American International Society for the Study of Xenobiotics meeting, in Boston, in September 2023, was held to explore current and emerging applications of quantitative proteomics in translational pharmacology and strategies for improved integration into model-informed drug development based on practical experience of each of the presenters. A summary of the talks and discussions is presented in this perspective alongside future outlook that was outlined for future meetings. SIGNIFICANCE STATEMENT: This perspective explores current and emerging applications of quantitative proteomics in translational pharmacology and precision medicine and outlines the outlook for improved integration into model-informed drug development.

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定量蛋白质组学在转化药理学和精准医学中的应用：技术现状与未来展望》。

在过去 20 年中，定量蛋白质组学贡献了大量蛋白质表达数据，这些数据目前用于各种系统药理学应用，作为相应蛋白质活性的补充或替代。2023 年 9 月在波士顿举行的第 25 届北美 ISSX 会议期间举办了一场专题讨论会，探讨定量蛋白质组学在转化药理学中的当前和新兴应用，以及根据每位发言人的实际经验将其更好地整合到以模型为依据的药物开发中的策略。本视角对会谈和讨论进行了总结，并对未来会议的前景进行了展望。意义声明本视角探讨了定量蛋白质组学在转化药理学和精准医学中的现有应用和新兴应用，并概述了如何将其更好地整合到以模型为依据的药物开发中。

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来源期刊

Drug Metabolism and Disposition 医学-药学

CiteScore

6.50

自引率

12.80%

发文量

128

审稿时长

3 months

期刊介绍： An important reference for all pharmacology and toxicology departments, DMD is also a valuable resource for medicinal chemists involved in drug design and biochemists with an interest in drug metabolism, expression of drug metabolizing enzymes, and regulation of drug metabolizing enzyme gene expression. Articles provide experimental results from in vitro and in vivo systems that bring you significant and original information on metabolism and disposition of endogenous and exogenous compounds, including pharmacologic agents and environmental chemicals.