Risk of autism spectrum disorder in children with infantile epileptic spasms syndrome: a retrospective study in a single center in Brazil

IF 2.8 4区 医学 Q1 PEDIATRICS Jornal de pediatria Pub Date : 2024-05-29 DOI:10.1016/j.jped.2024.04.006
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Abstract

Objective

This study aimed to investigate the prevalence of autism spectrum disorder and its possible correlations with clinical characteristics in patients with infantile epileptic spasms syndrome in a single center in Brazil.

Methods

This retrospective cross-sectional study examined 53 children with the diagnosis of infantile epileptic spasms syndrome prior to an autism spectrum disorder assessment. Participants were divided into two groups based on the presence or absence of autism spectrum disorder. Available variables (sex, medications, median age at onset of infantile epileptic spasms syndrome, and presence of comorbidities) were compared using Mann–Whitney U or chi-square tests.

Results

Among the included patients, 12 (23 %) were diagnosed with autism spectrum disorder, corresponding to a relative risk of 0.29 (95 % confidence interval 0.174–0.492). The age at the first seizure ranged from 3 to 15 months, with a mean of 6.65 months. This age significantly differed between participants with autism spectrum disorder (10.58 months) and those without (5.43 months), p<0.001.

Conclusion

Children with infantile epileptic spasms syndrome have a higher risk of being diagnosed with autism spectrum disorder. Later age of onset and period of spasm occurrence might be predisposing risk factors.

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婴幼儿癫痫痉挛综合征患儿患自闭症谱系障碍的风险:巴西一家中心的回顾性研究。
研究目的本研究旨在调查巴西一个中心的婴儿癫痫痉挛综合征患者中自闭症谱系障碍的患病率及其与临床特征的可能相关性:这项回顾性横断面研究对 53 名诊断为婴儿癫痫性痉挛综合征的儿童进行了自闭症谱系障碍评估。根据是否存在自闭症谱系障碍将参与者分为两组。采用曼-惠特尼U检验或卡方检验对现有变量(性别、药物、婴儿癫痫痉挛综合征发病年龄中位数和是否存在合并症)进行比较:在纳入的患者中,有 12 人(23%)被诊断患有自闭症谱系障碍,相对风险为 0.29(95% 置信区间为 0.174-0.492)。首次癫痫发作的年龄在 3 到 15 个月之间,平均为 6.65 个月。患有自闭症谱系障碍的患者(10.58 个月)与未患有自闭症谱系障碍的患者(5.43 个月)在这一年龄上存在明显差异,P= 结论:患有婴儿癫痫痉挛综合征的儿童被诊断为自闭症谱系障碍的风险较高。较晚的发病年龄和痉挛发生期可能是诱发风险因素。
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来源期刊
Jornal de pediatria
Jornal de pediatria 医学-小儿科
CiteScore
5.60
自引率
3.00%
发文量
93
审稿时长
43 days
期刊介绍: Jornal de Pediatria is a bimonthly publication of the Brazilian Society of Pediatrics (Sociedade Brasileira de Pediatria, SBP). It has been published without interruption since 1934. Jornal de Pediatria publishes original articles and review articles covering various areas in the field of pediatrics. By publishing relevant scientific contributions, Jornal de Pediatria aims at improving the standards of pediatrics and of the healthcare provided for children and adolescents in general, as well to foster debate about health.
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