Predictive value of circulating immune cell changes in response to PD-1 blockade and TKI therapy in patients with hepatocellular carcinoma

IF 2.6 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Clinics and research in hepatology and gastroenterology Pub Date : 2024-05-30 DOI:10.1016/j.clinre.2024.102390

Jianpeng Wang , Ping Xiao , Xishan Li , Wenyu Wu , Degang Shi , Wei Lin , Zuchang Wu

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Abstract

Purpose: This study investigated the dynamic changes in circulating immune cells following immune checkpoint inhibitors (ICIs), tyrosine kinase inhibitors (TKIs), and interventional therapy in hepatocellular carcinoma (HCC).

Methods: HCC patients undergoing transarterial chemoembolization (TACE), TKI, and ICI treatment were included in the treatment group. Peripheral blood samples were collected from these patients before each cycle of PD-1 blockade treatment. Flow cytometry analysis was conducted to assess the composition of peripheral immune cells and identify PD-1-expressing T cells.

Results: The treatment group showed a median time-to-tumor progression (TTP) of 8 months and an overall survival (OS) of 19 months. In comparison, the control group had 6 months and 15 months respectively. These differences were statistically significant (P = 0.029 for TTP and P = 0.020 for OS). In HCC patients receiving Lenvatinib, more circulating natural killer (NK) cells were noted. After 1–2 cycles of PD-1 antibody treatment, a general decline in the proportion of circulating PD-1⁺T cells was found, indicating individual variations in response.

Conclusion: Circulating immune cells have the potential to serve as indicators of the response to immunotherapy, providing a means to monitor dynamic changes and optimize treatment for HCC.

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肝细胞癌患者对 PD-1 阻断剂和 TKI 治疗反应的循环免疫细胞变化的预测价值。

目的：本研究调查了肝细胞癌（HCC）患者在接受免疫检查点抑制剂（ICIs）、酪氨酸激酶抑制剂（TKIs）和介入治疗后外周免疫细胞的动态变化。方法：将接受经动脉化疗栓塞（TACE）、TKI和ICI治疗的HCC患者纳入治疗组。在PD-1阻断剂治疗的每个周期前收集这些患者的外周血样本。流式细胞术分析评估了外周免疫细胞的组成，并确定了表达PD-1的T细胞：治疗组的中位肿瘤进展时间（TTP）为8个月，总生存期（OS）为19个月。相比之下，对照组分别为 6 个月和 15 个月。这些差异具有统计学意义（TTP=0.029，OS=0.020）。在接受乐伐替尼治疗的HCC患者中，循环中的自然杀伤（NK）细胞增多。经过1-2个周期的PD-1抗体治疗后，发现循环中PD-1+T细胞的比例普遍下降，这表明反应存在个体差异：循环免疫细胞有可能成为免疫疗法反应的指标，为监测动态变化和优化 HCC 治疗提供了一种手段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics and research in hepatology and gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.30

自引率

3.70%

发文量

198

审稿时长

42 days

期刊介绍： Clinics and Research in Hepatology and Gastroenterology publishes high-quality original research papers in the field of hepatology and gastroenterology. The editors put the accent on rapid communication of new research and clinical developments and so called "hot topic" issues. Following a clear Editorial line, besides original articles and case reports, each issue features editorials, commentaries and reviews. The journal encourages research and discussion between all those involved in the specialty on an international level. All articles are peer reviewed by international experts, the articles in press are online and indexed in the international databases (Current Contents, Pubmed, Scopus, Science Direct). Clinics and Research in Hepatology and Gastroenterology is a subscription journal (with optional open access), which allows you to publish your research without any cost to you (unless you proactively chose the open access option). Your article will be available to all researchers around the globe whose institution has a subscription to the journal.