Suppression of neointimal hyperplasia induced by arteriovenous anastomosis and balloon injury in rats by multimeric tumor necrosis factor-related apoptosis-inducing ligand

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecules and Cells Pub Date : 2024-06-01 DOI:10.1016/j.mocell.2024.100075

Ji Hye Han , Sun-Young Park , Seung-Hyun Myung , Junghee Park , Jeong Hwan Chang , Tae-Hyoung Kim

{"title":"Suppression of neointimal hyperplasia induced by arteriovenous anastomosis and balloon injury in rats by multimeric tumor necrosis factor-related apoptosis-inducing ligand","authors":"Ji Hye Han , Sun-Young Park , Seung-Hyun Myung , Junghee Park , Jeong Hwan Chang , Tae-Hyoung Kim","doi":"10.1016/j.mocell.2024.100075","DOIUrl":null,"url":null,"abstract":"<div>Excessive blood vessel wall thickening, known as intimal hyperplasia, can result from injury or inflammation and increase the risk of vascular diseases. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays key roles in tumor surveillance, autoimmune diseases, and apoptosis; however, its role in vascular stenosis remains controversial. Treatment with recombinant isoleucine zipper hexamerization domain soluble TRAIL (ILz(6):TRAIL) significantly inhibited the progression of neointimal hyperplasia (NH) induced by anastomosis of the carotid artery and jugular vein dose dependently, and adenovirus expressing secretable ILz(6):TRAIL also inhibited NH induced by balloon injury in the femoral artery of rats. This study demonstrated the preventive and partial regressive effects of ILz(6):TRAIL on anastomosis of the carotid artery and jugular vein- or balloon-induced NH.</div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1016847824001006/pdfft?md5=6bc819e1ad1f76549c11b98a7f732c79&pid=1-s2.0-S1016847824001006-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecules and Cells","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1016847824001006","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Excessive blood vessel wall thickening, known as intimal hyperplasia, can result from injury or inflammation and increase the risk of vascular diseases. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays key roles in tumor surveillance, autoimmune diseases, and apoptosis; however, its role in vascular stenosis remains controversial. Treatment with recombinant isoleucine zipper hexamerization domain soluble TRAIL (ILz(6):TRAIL) significantly inhibited the progression of neointimal hyperplasia (NH) induced by anastomosis of the carotid artery and jugular vein dose dependently, and adenovirus expressing secretable ILz(6):TRAIL also inhibited NH induced by balloon injury in the femoral artery of rats. This study demonstrated the preventive and partial regressive effects of ILz(6):TRAIL on anastomosis of the carotid artery and jugular vein- or balloon-induced NH.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

多聚肿瘤坏死因子相关凋亡诱导因子抑制动静脉吻合术和球囊损伤诱导的大鼠新内膜增生

血管壁过度增厚，即内膜增生，可由损伤或炎症引起，并增加罹患血管疾病的风险。肿瘤坏死因子相关凋亡诱导因子（TRAIL）在肿瘤监控、自身免疫性疾病和细胞凋亡中发挥着关键作用，但它在血管狭窄中的作用仍存在争议。用重组异亮氨酸拉链六聚体化结构域可溶性TRAIL（ILz(6):TRAIL）治疗可显著抑制颈动脉和颈静脉吻合（AAV）诱导的新内膜增生（NH）的进展，其剂量依赖性和表达可分泌ILz(6):TRAIL的腺病毒也可抑制大鼠股动脉球囊损伤诱导的NH。这项研究证明了ILz(6):TRAIL对AAV或气球诱导的NH具有预防和部分消退作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Molecules and Cells 生物-生化与分子生物学

CiteScore

6.60

自引率

10.50%

发文量

审稿时长

2.3 months

期刊介绍： Molecules and Cells is an international on-line open-access journal devoted to the advancement and dissemination of fundamental knowledge in molecular and cellular biology. It was launched in 1990 and ISO abbreviation is ''Mol. Cells''. Reports on a broad range of topics of general interest to molecular and cell biologists are published. It is published on the last day of each month by the Korean Society for Molecular and Cellular Biology.

期刊最新文献

The role of p21 in cellular senescence and aging-related diseases Cellular and metabolic function of GIRK1 potassium channels expressed by arcuate POMC and NPY/AgRP neurons Brief guide to flow cytometry Effects of phospholipase D1-inhibitory peptide on the growth and metastasis of gastric cancer cells The emerging role of gut hormones