From pill to pain: Alendronate-induced esophageal injury—A case report and review

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY JGH Open Pub Date : 2024-06-02 DOI:10.1002/jgh3.13080

Zhen Fan, Hayat Khizar, Jinjiao Lu, Anhua Wang, Tong Xun, Xiao Zhang, Hongfeng Zhao

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Abstract

Background

Alendronate is used to treat Paget's bone disease, glucocorticoid-induced osteoporosis, and postmenopausal osteoporosis because it suppresses osteoclast activity to stop bone resorption.

Case report

We present an exceptional case of esophagitis caused by alendronate. Blood tests and other data were normal when the patient was taken to the hospital, but an endoscopic examination revealed significant esophageal redness, erosion, and ulceration, along with pseudomembrane. The patient was given medicine after receiving a diagnosis of alendronate pill-induced esophagitis based on the pathological findings.

Conclusion

This case report is a timely reminder of the importance of thorough pharmacovigilance, patient education, and smart therapeutic decision-making in the context of alendronate use. To properly treat and prevent problems with the esophagus caused by alendronate, additional research is required.

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从药片到疼痛：阿仑膦酸钠诱发的食管损伤--病例报告和综述

背景阿仑膦酸钠用于治疗 Paget 骨病、糖皮质激素诱导的骨质疏松症和绝经后骨质疏松症，因为它能抑制破骨细胞的活性以阻止骨吸收。病例报告我们报告了一例阿仑膦酸钠引起食管炎的特殊病例。患者被送往医院时，血液化验和其他数据均正常，但内镜检查发现食管明显发红、糜烂和溃疡，并伴有假膜。根据病理检查结果，患者被诊断为阿仑膦酸钠药片诱发的食管炎，随后接受了药物治疗。结论本病例报告及时提醒了在使用阿仑膦酸钠时进行彻底的药物警戒、患者教育和明智的治疗决策的重要性。要正确治疗和预防阿仑膦酸钠引起的食道问题，还需要更多的研究。

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