Brief Report: Carboplatin, Weekly Paclitaxel and Pembrolizumab in Elderly Patients for Advanced Non-Small Cell Lung Cancer With PD-L1 < 50%: Real-World Data.

IF 3.3 3区 医学 Q2 ONCOLOGY Clinical lung cancer Pub Date : 2024-05-18 DOI:10.1016/j.cllc.2024.05.005
{"title":"Brief Report: Carboplatin, Weekly Paclitaxel and Pembrolizumab in Elderly Patients for Advanced Non-Small Cell Lung Cancer With PD-L1 < 50%: Real-World Data.","authors":"","doi":"10.1016/j.cllc.2024.05.005","DOIUrl":null,"url":null,"abstract":"<div><div><ul><li><span>•</span><span><div><span>Carboplatin<span>, weekly Paclitaxel (CwP) and </span></span>Pembrolizumab<span> is feasible in patients aged ≥70 with stage IV NSCLC and PD-L1 &lt; 50%</span></div></span></li><li><span>•</span><span><div>Progression-Free Survival and Overall Survival are improved with addition of Pembrolizumab to CwP in this population</div></span></li><li><span>•</span><span><div>Toxicity profile is consistent with that of other populations, although with a higher frequency of anemia</div></span></li><li><span>•</span><span><div>Addition of Pembrolizumab to CwP should be considered in selected patients aged ≥ 70 with stage IV NSCLC and PD-L1 &lt; 50%</div></span></li></ul></div></div>","PeriodicalId":10490,"journal":{"name":"Clinical lung cancer","volume":"25 7","pages":"Pages e323-e329"},"PeriodicalIF":3.3000,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical lung cancer","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1525730424000846","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

  • Carboplatin, weekly Paclitaxel (CwP) and Pembrolizumab is feasible in patients aged ≥70 with stage IV NSCLC and PD-L1 < 50%
  • Progression-Free Survival and Overall Survival are improved with addition of Pembrolizumab to CwP in this population
  • Toxicity profile is consistent with that of other populations, although with a higher frequency of anemia
  • Addition of Pembrolizumab to CwP should be considered in selected patients aged ≥ 70 with stage IV NSCLC and PD-L1 < 50%
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
简要报告卡铂、每周紫杉醇和 Pembrolizumab 用于 PD-L1 < 50% 的晚期非小细胞肺癌老年患者:真实世界数据。
-卡铂、每周紫杉醇(CwP)和 Pembrolizumab 可用于年龄≥70 岁的 IV 期 NSCLC 患者,且 PD-L1 <;Pembrolizumab在CwP中的应用提高了无进展生存期和总生存期-毒性特征与其他人群一致,但贫血发生率较高-在CwP中添加Pembrolizumab,应考虑用于年龄≥70岁的IV期NSCLC和PD-L1 <50%的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Clinical lung cancer
Clinical lung cancer 医学-肿瘤学
CiteScore
7.00
自引率
2.80%
发文量
159
审稿时长
24 days
期刊介绍: Clinical Lung Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of lung cancer. Clinical Lung Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of lung cancer. The main emphasis is on recent scientific developments in all areas related to lung cancer. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.
期刊最新文献
Editorial Board Table of Contents Radiologists Versus AI-Based Software: Predicting Lymph Node Metastasis and Prognosis in Lung Adenocarcinoma From CT Under Various Image Display Conditions. Biomarker Landscape of Antibody Drug Conjugates (ADCs) and Bispecific Antibodies in Clinical Trials for Lung Cancer. Brief Report: Phase II Clinical Trial of Atezolizumab in Advanced Nonsmall Cell Lung Cancer Patients Previously Treated With PD-1-Directed Therapy.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1