Nosocomial outbreak of SARS-CoV-2 in a hospital ward during the Omicron variant-dominant wave with a review of the relevant literature

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Japanese journal of infectious diseases Pub Date : 2024-05-31 DOI:10.7883/yoken.jjid.2023.464
Hilary Osaka, Yasuaki Tagashira, Hiroaki Takeuchi, Yukie Tanaka, Kousuke Tanimoto, Yoshiaki Gu
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Abstract

Clusters of nosocomial coronavirus disease 2019 (COVID-19) were reported globally during the recent pandemic. Unfortunately, these clusters negatively impacted inpatient morbidity, mortality, and hospital functions. Using epidemiological data and whole genome sequencing (WGS) of SARS-CoV-2, the present study investigated an outbreak of COVID-19 at a university hospital. Eight inpatients and 13 healthcare workers tested positive for SARS-CoV-2 during a one-month period. Whole genome sequencing (WGS) of the virus in 11 patients revealed that two variants of concern belonging to the Omicron sublineages, BA.2.3 and BA1.1.2, had caused the outbreak during a time when the proportion of the Omicron lineage in the community was changing. When variants of concern are undergoing mutation, a response to the outbreak should be made with multiple variants in mind, even in the absence of epidemiological data showing close contact or other potential vectors of infection, and awareness about infection prevention and control should be raised to safeguard patient safety.

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奥米克龙变异主导潮期间某医院病房爆发的非典型肺炎-CoV-2疫情及相关文献综述
在最近的大流行病期间,全球各地都报告了冠状病毒病 2019(COVID-19)集群。不幸的是,这些集群对住院病人的发病率、死亡率和医院功能造成了负面影响。本研究利用流行病学数据和 SARS-CoV-2 的全基因组测序(WGS),对一家大学医院爆发的 COVID-19 进行了调查。在一个月的时间里,8 名住院病人和 13 名医护人员的 SARS-CoV-2 检测结果呈阳性。对 11 名患者的病毒进行的全基因组测序(WGS)显示,属于 Omicron 亚系的两个变种 BA.2.3 和 BA1.1.2 引起了疫情的爆发,而此时 Omicron 亚系在社区中的比例正在发生变化。当令人担忧的变种正在发生变异时,即使没有流行病学数据表明存在密切接触或其他潜在的感染媒介,也应考虑到多种变种,对疫情做出反应,并提高对感染预防和控制的认识,以保障病人的安全。
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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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