S. Sandra, D. R. Anakha, Cheriyan Silpa, T. V. Vyshnavi, M. Bhagiyalakshmi, R. Yamuna, M. Karthega
{"title":"Synthesis of electrospun PVA/chitosan nanofibrous scaffold impregnated with CuO nanoparticles for wound healing","authors":"S. Sandra, D. R. Anakha, Cheriyan Silpa, T. V. Vyshnavi, M. Bhagiyalakshmi, R. Yamuna, M. Karthega","doi":"10.1007/s10570-024-05960-3","DOIUrl":null,"url":null,"abstract":"<p>In the current study, cupric oxide nanoparticles (CuO NPs) are chemically synthesized and blended with polyvinyl alcohol and chitosan (PVA-CS) solution to produce nanofibrous wound dressing material using an electrospinning technique. The fibrous morphology of CuO-blended nanofibers was studied by SEM, showing smooth beads and uniform nanofibers with an average diameter of around 86.4 nm. The nanofibers are further characterized using XRD to confirm the presence of CuO NPs. The incorporation of CuO NPs with polymer is evident from the peaks obtained from infrared spectrum. The addition of CuO NPs retained the hydrophilic nature of scaffold, as evident from the contact angle measurement. Further, the wound healing properties of scaffold are apparent from the studies such as antioxidant activity, MTT assay, wound scratch assay, and antibacterial studies. These results indicate the greater efficacy of CuO NPs incorporated in PVA/CS for wound healing applications.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>","PeriodicalId":511,"journal":{"name":"Cellulose","volume":null,"pages":null},"PeriodicalIF":4.9000,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellulose","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1007/s10570-024-05960-3","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, PAPER & WOOD","Score":null,"Total":0}
引用次数: 0
Abstract
In the current study, cupric oxide nanoparticles (CuO NPs) are chemically synthesized and blended with polyvinyl alcohol and chitosan (PVA-CS) solution to produce nanofibrous wound dressing material using an electrospinning technique. The fibrous morphology of CuO-blended nanofibers was studied by SEM, showing smooth beads and uniform nanofibers with an average diameter of around 86.4 nm. The nanofibers are further characterized using XRD to confirm the presence of CuO NPs. The incorporation of CuO NPs with polymer is evident from the peaks obtained from infrared spectrum. The addition of CuO NPs retained the hydrophilic nature of scaffold, as evident from the contact angle measurement. Further, the wound healing properties of scaffold are apparent from the studies such as antioxidant activity, MTT assay, wound scratch assay, and antibacterial studies. These results indicate the greater efficacy of CuO NPs incorporated in PVA/CS for wound healing applications.
期刊介绍：
Cellulose is an international journal devoted to the dissemination of research and scientific and technological progress in the field of cellulose and related naturally occurring polymers. The journal is concerned with the pure and applied science of cellulose and related materials, and also with the development of relevant new technologies. This includes the chemistry, biochemistry, physics and materials science of cellulose and its sources, including wood and other biomass resources, and their derivatives. Coverage extends to the conversion of these polymers and resources into manufactured goods, such as pulp, paper, textiles, and manufactured as well natural fibers, and to the chemistry of materials used in their processing. Cellulose publishes review articles, research papers, and technical notes.
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