Effect of Citrate on Morphological and Structural Properties of Hydroxyapatite Nanoparticles Synthesized by Wet Chemical Precipitation Method

IF 1.4 4区化学 Q4 CHEMISTRY, PHYSICAL Colloid Journal Pub Date : 2024-05-30 DOI:10.1134/S1061933X24600027

Thoudam Chanchan Devi, Ngasepam Bhogenjit Singh, Thiyam David Singh

{"title":"Effect of Citrate on Morphological and Structural Properties of Hydroxyapatite Nanoparticles Synthesized by Wet Chemical Precipitation Method","authors":"Thoudam Chanchan Devi, Ngasepam Bhogenjit Singh, Thiyam David Singh","doi":"10.1134/S1061933X24600027","DOIUrl":null,"url":null,"abstract":"Hydroxyapatite (HAp) nanoparticles organically modified with citrate group are fabricated via a simple wet chemical precipitation method. The as-synthesized nanoparticles are structurally characterized by TEM, XRD, FT-IR, EDAX and dynamic light scattering (DLS) to investigate in detail the influence of surface coating ligand i.e. citrate on HAp morphology, crystal structure, phase and colloidal stability of the particles. Production of single phase with hexagonal crystal structure is evident by XRD analysis. The work shows mesoporous structure could be synthesized under the influence of citrate as confirmed by TEM image and N2 adsorption−desorption isotherm. The experimental results indicate that citrate strongly influences HAp crystallization giving reduced particle size and uniform distribution. BET and BJH analysis indicate large surface area 135.74 m2/g and pore diameter of 9.86 nm with a total pore volume of 0.41 cm3/g respectively for 1 : 1 citrate to calcium ion molar ratio. The appropriate surface area and pore entrance significantly indicate potentiality to apply into biomedical fields as drug loading/delivery application.","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloid Journal","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1061933X24600027","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Hydroxyapatite (HAp) nanoparticles organically modified with citrate group are fabricated via a simple wet chemical precipitation method. The as-synthesized nanoparticles are structurally characterized by TEM, XRD, FT-IR, EDAX and dynamic light scattering (DLS) to investigate in detail the influence of surface coating ligand i.e. citrate on HAp morphology, crystal structure, phase and colloidal stability of the particles. Production of single phase with hexagonal crystal structure is evident by XRD analysis. The work shows mesoporous structure could be synthesized under the influence of citrate as confirmed by TEM image and N₂ adsorption−desorption isotherm. The experimental results indicate that citrate strongly influences HAp crystallization giving reduced particle size and uniform distribution. BET and BJH analysis indicate large surface area 135.74 m²/g and pore diameter of 9.86 nm with a total pore volume of 0.41 cm³/g respectively for 1 : 1 citrate to calcium ion molar ratio. The appropriate surface area and pore entrance significantly indicate potentiality to apply into biomedical fields as drug loading/delivery application.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

柠檬酸盐对湿化学沉淀法合成的羟基磷灰石纳米粒子形态和结构特性的影响

摘要通过简单的湿化学沉淀法制备了柠檬酸基有机修饰的羟基磷灰石（HAp）纳米粒子。通过 TEM、XRD、FT-IR、EDAX 和动态光散射（DLS）对合成的纳米颗粒进行结构表征，以详细研究表面涂层配体（即柠檬酸盐）对颗粒的 HAp 形貌、晶体结构、相和胶体稳定性的影响。通过 XRD 分析，可以明显看出生成了具有六方晶体结构的单相。工作表明，在柠檬酸盐的影响下可以合成介孔结构，TEM 图像和 N2 吸附-解吸等温线证实了这一点。实验结果表明，柠檬酸盐强烈影响了 HAp 的结晶，使其粒径减小，分布均匀。BET 和 BJH 分析表明，柠檬酸盐与钙离子摩尔比为 1 : 1 时，表面积为 135.74 m2/g，孔径为 9.86 nm，总孔容积为 0.41 cm3/g。适当的表面积和孔隙入口极大地显示了将其应用于生物医学领域作为药物装载/输送应用的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Colloid Journal 化学-物理化学

CiteScore

2.20

自引率

18.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Colloid Journal (Kolloidnyi Zhurnal) is the only journal in Russia that publishes the results of research in the area of chemical science dealing with the disperse state of matter and surface phenomena in disperse systems. The journal covers experimental and theoretical works on a great variety of colloid and surface phenomena: the structure and properties of interfaces; adsorption phenomena and structure of adsorption layers of surfactants; capillary phenomena; wetting films; wetting and spreading; and detergency. The formation of colloid systems, their molecular-kinetic and optical properties, surface forces, interaction of colloidal particles, stabilization, and criteria of stability loss of different disperse systems (lyosols and aerosols, suspensions, emulsions, foams, and micellar systems) are also topics of the journal. Colloid Journal also includes the phenomena of electro- and diffusiophoresis, electro- and thermoosmosis, and capillary and reverse osmosis, i.e., phenomena dealing with the existence of diffusion layers of molecules and ions in the vicinity of the interface.