The Effect of Omega-3 Supplementation on Heart Failure Outcome: A Meta-Analysis of Randomized Clinical Trial.

Q2 Medicine Journal of Lipid and Atherosclerosis Pub Date : 2024-05-01 Epub Date: 2023-12-07 DOI:10.12997/jla.2024.13.2.89

Bambang Dwiputra, Ade Meidian Ambari, Dwita Rian Desandri, Budhi Setianto Purwowiyoto, Basuni Radi, Bashar Adi Wahyu Pandhita, Serlie Fatrin, Anwar Santoso

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Abstract

The effect of omega-3 supplementation on cardiovascular (CV) disease has been widely studied in several large clinical trials. However, the evidence of the effect of omega-3 supplementation in patients with heart failure (HF) remains controversial. This meta-analysis investigated the effects of omega-3 supplementation on patients with HF. We conducted a literature search on MEDLINE, Embase, and Cochrane databases for clinical trials and preprints of relevant articles. Following a literature search and critical appraisal, 5 studies were included in the meta-analysis. The pooling of the result of the studies shows that there were no significant association between omega-3 supplementation and CV mortality (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.84-1.05, p=0.16) nor hospitalization due to HF (OR, 0.94; 95% CI, 0.88-1.02; p=0.13). Our systematic review and meta-analysis showed that omega-3 supplementation has no beneficial effect in patients with HF.

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补充 Omega-3 对心力衰竭结果的影响：随机临床试验的 Meta 分析。

多项大型临床试验已广泛研究了补充欧米伽-3 对心血管疾病的影响。然而，有关补充欧米伽-3对心力衰竭（HF）患者影响的证据仍存在争议。这项荟萃分析研究了补充欧米伽-3 对心力衰竭患者的影响。我们在 MEDLINE、Embase 和 Cochrane 数据库中对临床试验和相关文章的预印本进行了文献检索。经过文献检索和严格评审，5 项研究被纳入荟萃分析。汇总研究结果显示，补充欧米伽-3与心血管疾病死亡率（几率比[OR]，0.94；95% 置信区间[CI]，0.84-1.05；P=0.16）和心房颤动住院率（几率比，0.94；95% 置信区间[CI]，0.88-1.02；P=0.13）之间没有显著关联。我们的系统综述和荟萃分析表明，补充欧米伽-3对心房颤动患者没有益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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