The Prognostic Value of the Triglyceride-Glucose Index in Forecasting Ten-Year Major Adverse Cardiovascular Events in Non-Diabetic Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention.

Uğur Köktürk, Orhan Onalan, Mustafa Umut Somuncu, Begüm Uygur, İlke Erbay, Fahri Çakan, Ahmet Avcı
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Abstract

Objective: This study aimed to explore the association between the triglyceride-glucose (TyG) index and major adverse cardiovascular events (MACE) over a ten-year period in non-diabetic patients with acute myocardial infarction (MI) undergoing primary percutaneous coronary intervention (PCI).

Methods: We included 375 consecutive non-diabetic patients presenting with acute MI who underwent primary PCI. The TyG index was calculated and patients were divided based on a cut-off value of ≥ 8.84 into high and low TyG index groups. The incidence of MACE, including all-cause mortality, target vessel revascularization, reinfarction, and rehospitalization for heart failure, was assessed over 10 years.

Results: Over the next 10 years, patients who underwent PCI for acute MI experienced a significantly higher incidence of MACE in the group with a high TyG index (≥ 8.84) (P = 0.004). Multivariable analysis revealed that the TyG index independently predicted MACE in these patients [odds ratio = 1.64; 95% confidence interval (CI): 1.22-2.21; P = 0.002]. Analysis of the receiver operating characteristic curve indicated that the TyG index effectively predicted MACE in patients with acute MI following PCI, with an area under the curve of 0.562 (95% CI: 0.503-0.621; P = 0.038).

Conclusion: This study established a correlation between high TyG index levels and an elevated risk of MACE in non-diabetic patients with acute MI. The findings suggest that the TyG index could be a reliable indicator of clinical outcomes for non-diabetic acute MI patients undergoing PCI.

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甘油三酯-葡萄糖指数在预测接受经皮冠状动脉介入治疗的非糖尿病急性心肌梗死患者十年主要不良心血管事件中的预后价值。
研究目的本研究旨在探讨接受一级经皮冠状动脉介入治疗(PCI)的非糖尿病急性心肌梗死(MI)患者的甘油三酯-葡萄糖(TyG)指数与十年内主要不良心血管事件(MACE)之间的关系:我们连续纳入了 375 名接受初级 PCI 治疗的急性心肌梗死非糖尿病患者。计算TyG指数,并根据≥8.84的临界值将患者分为高TyG指数组和低TyG指数组。评估了10年内MACE的发生率,包括全因死亡率、靶血管血运重建、再梗死和心衰再住院:在接下来的10年中,因急性心肌梗死接受PCI治疗的患者中,TyG指数高(≥ 8.84)组的MACE发生率明显更高(P = 0.004)。多变量分析显示,TyG 指数可独立预测这些患者的 MACE [几率比 = 1.64;95% 置信区间 (CI):1.22-2.21;P = 0.002]。接收者操作特征曲线分析表明,TyG指数可有效预测PCI术后急性心肌梗死患者的MACE,曲线下面积为0.562(95% CI:0.503-0.621;P = 0.038):本研究确定了高TyG指数水平与非糖尿病急性心肌梗死患者MACE风险升高之间的相关性。研究结果表明,TyG指数可作为接受PCI治疗的非糖尿病急性心肌梗死患者临床预后的可靠指标。
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