Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY Neurobiology of Aging Pub Date : 2024-06-01 DOI:10.1016/j.neurobiolaging.2024.05.015

Blanca Rodríguez-Fernández , Gonzalo Sánchez-Benavides , Patricia Genius , Carolina Minguillon , Karine Fauria , Immaculata De Vivo , Arcadi Navarro , Jose Luis Molinuevo , Juan Domingo Gispert , Aleix Sala-Vila , Natalia Vilor-Tejedor , Marta Crous-Bou , for the ALFA study

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Abstract

Introduction

Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD.

Methods

A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested.

Results

Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group.

Discussion

Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns.

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端粒长度与阿尔茨海默氏症高危人群认知功能之间的关系。

引言白细胞端粒长度（LTL）是生物衰老的客观生物标志物，被认为在阿尔茨海默病（AD）风险中起着至关重要的作用。我们的目的是评估LTL与认知能力之间的横断面关系，研究对象是认知能力未受损且罹患阿尔茨海默病风险增加的中年人。通过 qPCR 测量了白细胞中端粒的相对长度。根据年龄和性别对端粒长度进行残差，并根据残差端粒长度（rLTL）评估短端粒组和长端粒组与认知能力的关系。结果发现LTL与外显记忆（EM）之间存在非线性关联。讨论结果表明，端粒在认知老化过程中的潜在作用具有性别特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Aging 医学-老年医学

CiteScore

8.40

自引率

2.40%

发文量

225

审稿时长

67 days

期刊介绍： Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.