A predictive model for HIV-related lymphoma.

IF 3.4 2区 医学 Q3 IMMUNOLOGY AIDS Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI:10.1097/QAD.0000000000003949
Shuhei Kurosawa, Yukihiro Yoshimura, Yusuke Takada, Takako Yokota, Masaki Hibi, Ayumi Hirahara, Tsutomu Yoshida, So Okubo, Moe Masuda, Yuna So, Nobuyuki Miyata, Hitomi Nakayama, Aki Sakurai, Kosuke Sato, Chisako Ito, Yoshinobu Aisa, Tomonori Nakazato
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Abstract

Objectives: To address the paucity of HIV-related lymphoma (HRL)-specific prognostic scores for the Japanese population by analyzing domestic cases of HRL and constructing a predictive model.

Design: A single-center retrospective study coupled with a review of case reports of HRL.

Methods: We reviewed all patients with HRL treated at our hospital between 2007 and 2023 and conducted a comprehensive search for case reports of HRL from Japan using public databases. A multivariate analysis for overall survival (OS) was performed using clinical parameters, leading to the formulation of the HIV-Japanese Prognostic Index (HIV-JPI).

Results: A total of 19 patients with HRL were identified in our institution, whereas the literature review yielded 44 cases. In the HIV-JPI, a weighted score of 1 was assigned to the following factors: age at least 45 years, HIV-RNA at least 8.0×10 4  copies/ml, Epstein-Barr virus-encoded small RNA positivity, and Ann Arbor classification stage IV. The overall score ranged from 0 to 4. We defined the low-risk group as scores ranging from 0 to 2 and the high-risk group as scores ranging from 3 to 4. The 3-year OS probability of the high-risk group [30.8%; 95% confidence interval (CI): 9.5-55.4%) was significantly poorer than that of the low-risk group (76.8%; 95% CI: 52.8-89.7%; P  < 0.01).

Conclusion: This retrospective analysis established pivotal prognostic factors for HRL in Japanese patients. The HIV-JPI, derived exclusively from Japanese patients, highlights the potential for stratified treatments and emphasizes the need for broader studies to further refine this clinical prediction model.

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艾滋病相关淋巴瘤的预测模型:日本的病例系列和文献综述。
目的通过分析日本国内与人类免疫缺陷病毒(HIV)相关的淋巴瘤(HRL)病例并构建预测模型,以解决日本人群中人类免疫缺陷病毒(HIV)相关淋巴瘤(HRL)特异性预后评分缺乏的问题:设计:单中心回顾性研究,同时回顾HRL病例报告:我们回顾了2007年至2023年间在我院接受治疗的所有HRL患者,并利用公共数据库对日本的HRL病例报告进行了全面检索。我们利用临床参数对总生存率(OS)进行了多变量分析,并据此制定了HIV-日本预后指数(HIV-JPI):结果:我院共发现 19 例 HRL 患者,而文献综述则有 44 例。在 HIV-JPI 中,以下因素的加权分数为 1:年龄≥45 岁、HIV-RNA ≥8.0×104 copies/mL、Epstein-Barr 病毒编码的小 RNA 阳性、Ann Arbor 分类 IV 期。高风险组的 3 年 OS 概率(30.8%;95% 置信区间 [CI]:9.5%-55.4%)明显低于低风险组(76.8%;95% CI:52.8%-89.7%;P 结论:这项回顾性分析确定了日本患者 HRL 的关键预后因素。仅从日本患者中得出的 HIV-JPI 强调了分层治疗的潜力,并强调有必要进行更广泛的研究,以进一步完善这一临床预测模型。
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来源期刊
AIDS
AIDS 医学-病毒学
CiteScore
5.90
自引率
5.30%
发文量
478
审稿时长
3 months
期刊介绍: ​​​​​​​​​​​​​​​​​Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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