Effect of the COVID-19 pandemic on clinical characteristics and outcomes of adult pneumococcal meningitis patients - a Dutch prospective nationwide cohort study.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES Infection Pub Date : 2024-10-01 Epub Date: 2024-06-03 DOI:10.1007/s15010-024-02305-x

Fabian D Liechti, Merijn W Bijlsma, Matthijs C Brouwer, Diederik van de Beek

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Abstract

Purpose: To investigate clinical characteristics and outcomes of patients with pneumococcal meningitis during the COVID-19 pandemic.

Methods: In a Dutch prospective cohort, risk factors and clinical characteristics of pneumococcal meningitis episodes occurring during the COVID-19 pandemic (starting March 2020) were compared with those from baseline and the time afterwards. Outcomes were compared with an age-adjusted logistic regression model.

Results: We included 1,699 patients in 2006-2020, 50 patients in 2020-2021, and 182 patients in 2021-2023. After March 2020 relatively more alcoholism was reported (2006-2020, 6.1%; 2020-2021, 18%; 2021-2023, 9.7%; P = 0.002) and otitis-sinusitis was less frequently reported (2006-2020, 45%; 2020-2021, 22%; 2021-2023, 47%; P = 0.006). Other parameters, i.e. age, sex, symptom duration or initial C-reactive protein level, remained unaffected. Compared to baseline, lumbar punctures were more frequently delayed (on admission day, 2006-2020, 89%; 2020-2021, 74%; 2021-2022, 86%; P = 0.002) and outcomes were worse ('good recovery', 2020-2021, OR 0.5, 95% CI 0.3-0.8).

Conclusion: During the COVID-19 pandemic, we observed worse outcomes in patients with pneumococcal meningitis. This may be explained by differing adherence to restrictions according to risk groups or by reduced health care quality.

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COVID-19 大流行对成年肺炎球菌脑膜炎患者临床特征和预后的影响--荷兰前瞻性全国队列研究。

目的：研究COVID-19大流行期间肺炎球菌脑膜炎患者的临床特征和预后：在荷兰的一个前瞻性队列中，将 COVID-19 大流行期间（2020 年 3 月开始）发生的肺炎球菌脑膜炎病例的风险因素和临床特征与基线及之后的风险因素和临床特征进行了比较。结果采用年龄调整后的逻辑回归模型进行比较：我们纳入了 2006-2020 年的 1,699 名患者、2020-2021 年的 50 名患者和 2021-2023 年的 182 名患者。2020 年 3 月以后报告的酗酒患者相对较多（2006-2020 年，6.1%；2020-2021 年，18%；2021-2023 年，9.7%；P = 0.002），报告的耳炎-鼻窦炎患者较少（2006-2020 年，45%；2020-2021 年，22%；2021-2023 年，47%；P = 0.006）。其他参数，如年龄、性别、症状持续时间或初始 C 反应蛋白水平，均未受到影响。与基线相比，腰椎穿刺更常延迟（入院当天，2006-2020 年，89%；2020-2021 年，74%；2021-2022 年，86%；P = 0.002），结果也更差（"恢复良好"，2020-2021 年，OR 0.5，95% CI 0.3-0.8）：结论：在 COVID-19 大流行期间，我们观察到肺炎球菌脑膜炎患者的预后较差。结论：在 COVID-19 大流行期间，我们观察到肺炎球菌脑膜炎患者的预后较差，这可能是由于不同风险群体对限制措施的遵守情况不同或医疗质量下降所致。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.