Differences in brain functional connectivity between tinnitus with or without hearing loss.

IF 1.6 4区医学 Q4 NEUROSCIENCES Neuroreport Pub Date : 2024-08-07 Epub Date: 2024-06-03 DOI:10.1097/WNR.0000000000002057

Jianxiong Song, Yuanyuan Wang, Fang Ouyang, Xianjun Zeng, Jian Yang

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Abstract

To explore the differences in brain imaging in tinnitus with or without hearing loss (HL). We acquired functional MRI scans from 26 tinnitus patients with HL (tinnitus-HL), 24 tinnitus patients with no HL (tinnitus-NHL), and 26 healthy controls (HCs) matched by age and sex. The left and right thalamus were selected as seeds to study the endogenous functional connectivity (FC) of the whole brain, and its correlation with clinical indices was analyzed. Brain regions showing FC differences among the three groups included the Heschl gyrus (HES), right Hippocampus (HIP), right Amygdala (AMYG), left Calcarine fissure and surrounding cortex (CAL). Post hoc analysis showed that the thalamus-HIP connection and thalamus-lingual gyrus (LING) connection were enhanced in the tinnitus-NHL group, as compared to tinnitus-HL. Compared with HCs, the tinnitus-NHL group showed an enhanced connection between the thalamus and the left Inferior occipital gyrus, left CAL and LING. While in the tinnitus-HL group, the connection between the thalamus and several brain regions (right HES, right AMYG, etc) was weakened. In the tinnitus-HL group, the tinnitus handicap inventory scores were positively correlated with the FC of the left thalamus and right HES, right thalamus and right Rolandic operculum. The duration of tinnitus was negatively correlated with the FC of the right thalamus and right HIP. Abnormal FC in the thalamus may play an important role in the pathogenesis of tinnitus. Tinnitus-NHL and tinnitus-HL show different connection patterns, indicating that there are some differences in their pathogenesis.

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伴有或不伴有听力损失的耳鸣患者大脑功能连接的差异。

目的：探讨有无听力损失（HL）的耳鸣患者大脑成像的差异。我们采集了 26 名有听力损失（HL）的耳鸣患者（耳鸣-HL）、24 名没有听力损失（HL）的耳鸣患者（耳鸣-NHL）以及 26 名年龄和性别匹配的健康对照组（HCs）的功能磁共振成像扫描。研究人员选取了左右丘脑作为研究全脑内源性功能连接（FC）的种子，并分析了其与临床指标的相关性。三组之间出现功能连接差异的脑区包括赫氏回（HES）、右侧海马（HIP）、右侧杏仁核（AMYG）、左侧钙化裂及其周围皮层（CAL）。事后分析表明，与耳鸣-HL组相比，耳鸣-NHL组丘脑-HIP连接和丘脑-舌回（LING）连接增强。与 HCs 相比，耳鸣-NHL 组的丘脑与左枕下回、左 CAL 和 LING 之间的连接增强。而在耳鸣-HL 组中，丘脑与多个脑区（右 HES、右 AMYG 等）之间的联系减弱。在耳鸣-HL 组中，耳鸣障碍量表评分与左丘脑和右 HES、右丘脑和右 Rolandic operculum 的 FC 值呈正相关。耳鸣持续时间与右丘脑和右 HIP 的 FC 呈负相关。丘脑的FC异常可能在耳鸣的发病机制中扮演重要角色。耳鸣-NHL和耳鸣-HL表现出不同的连接模式，表明它们的发病机制存在一定差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroreport 医学-神经科学

CiteScore

3.20

自引率

0.00%

发文量

150

审稿时长

1 months

期刊介绍： NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.