The effect of curcumin on paraoxonase 1 protein levels, gene expression, and enzyme activity: A systematic review of animal interventional studies

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Prostaglandins & other lipid mediators Pub Date : 2024-06-01 DOI:10.1016/j.prostaglandins.2024.106849

Fatemeh Hamedi-Kalajahi , Mohammad Alizadeh , Sorayya Kheirouri , Roghayeh Molani-Gol

{"title":"The effect of curcumin on paraoxonase 1 protein levels, gene expression, and enzyme activity: A systematic review of animal interventional studies","authors":"Fatemeh Hamedi-Kalajahi , Mohammad Alizadeh , Sorayya Kheirouri , Roghayeh Molani-Gol","doi":"10.1016/j.prostaglandins.2024.106849","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and aims</h3><p>Paraoxonase (PON) proteins have various hydrolytic activities. The PON family is able to detoxify oxidized low-density lipoprotein. Additionally, differentiation of monocytes into macrophages, as the first stage in the development of atherosclerosis, is suppressed by PON 1. The effects of polyphenols including curcumin on PON1 have been investigated in studies. In this study, our main goal is to investigate curcumin’s effect on PON1 protein levels, gene expression, and enzyme activity in animal interventional studies.</p></div><div><h3>Methods</h3><p>The literature was searched through the online databases including PubMed, SCOPUS, Embase, and Google Scholar until May 2022.</p></div><div><h3>Results</h3><p>Curcumin administration can increase the PON1 enzyme activity. Also, it probably has a positive role in increasing the PON1 gene expression. However, concerning the PON1 protein values, results are contradictory.</p></div><div><h3>Conclusions</h3><p>The findings of this study suggested positive role of curcumin in increasing PON1 enzyme activities, gene expression, and protein levels.</p></div><div><h3>Data Availability</h3><p>Data are available from the corresponding author (<span><span>[email protected]</span></span><svg><path></path></svg>)</p></div>","PeriodicalId":21161,"journal":{"name":"Prostaglandins & other lipid mediators","volume":"174 ","pages":"Article 106849"},"PeriodicalIF":2.5000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins & other lipid mediators","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1098882324000431","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background and aims

Paraoxonase (PON) proteins have various hydrolytic activities. The PON family is able to detoxify oxidized low-density lipoprotein. Additionally, differentiation of monocytes into macrophages, as the first stage in the development of atherosclerosis, is suppressed by PON 1. The effects of polyphenols including curcumin on PON1 have been investigated in studies. In this study, our main goal is to investigate curcumin’s effect on PON1 protein levels, gene expression, and enzyme activity in animal interventional studies.

Methods

The literature was searched through the online databases including PubMed, SCOPUS, Embase, and Google Scholar until May 2022.

Results

Curcumin administration can increase the PON1 enzyme activity. Also, it probably has a positive role in increasing the PON1 gene expression. However, concerning the PON1 protein values, results are contradictory.

Conclusions

The findings of this study suggested positive role of curcumin in increasing PON1 enzyme activities, gene expression, and protein levels.

Data Availability

Data are available from the corresponding author ([email protected])

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

姜黄素对副氧自由基酶 1 蛋白水平、基因表达和酶活性的影响：动物干预研究的系统综述》。

背景与目的：顺氧化酶（PON）蛋白具有多种水解活性。PON 家族能够对氧化的低密度脂蛋白进行解毒。此外，作为动脉粥样硬化发展的第一阶段，单核细胞向巨噬细胞的分化会受到 PON 1 的抑制。有研究调查了包括姜黄素在内的多酚对 PON1 的影响。在本研究中，我们的主要目标是在动物干预研究中调查姜黄素对 PON1 蛋白水平、基因表达和酶活性的影响：方法：通过PubMed、SCOPUS、Embase和Google Scholar等在线数据库检索截至2022年5月的文献：结果：姜黄素能提高 PON1 酶的活性。结果：姜黄素能提高 PON1 酶的活性，还可能对增加 PON1 基因表达有积极作用。然而，关于 PON1 蛋白的数值，结果却相互矛盾：本研究结果表明姜黄素在提高 PON1 酶活性、基因表达和蛋白质水平方面具有积极作用：数据可从通讯作者处获得 (Kheirouris@tbzmed.ac.ir)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Prostaglandins & other lipid mediators 生物-生化与分子生物学

CiteScore

5.80

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It includes basic and clinical studies related to the pharmacology, physiology, pathology and biochemistry of lipid mediators. Prostaglandins & Other Lipid Mediators invites reports of original research, mini-reviews, reviews, and methods articles in the basic and clinical aspects of all areas of lipid mediator research: cell biology, developmental biology, genetics, molecular biology, chemistry, biochemistry, physiology, pharmacology, endocrinology, biology, the medical sciences, and epidemiology. Prostaglandins & Other Lipid Mediators also accepts proposals for special issue topics. The Editors will make every effort to advise authors of the decision on the submitted manuscript within 3-4 weeks of receipt.