[Bone mineral density in women with rheumatoid arthritis: A link between immune and biochemical markers].

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Terapevticheskii Arkhiv Pub Date : 2024-06-03 DOI:10.26442/00403660.2024.05.202705

O V Dobrovolskaya, N V Demin, M V Kozyreva, E Y Samarkina, M E Diatroptov, N V Toroptsova

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Abstract

Aim: To study the association of bone mineral density (BMD) with serum biochemical and immunological markers in postmenopausal women with rheumatoid arthritis (RA).

Materials and methods: The study included 173 women with RA (age 61.0 [56.0; 66.0] years). A survey, dual-energy X-ray absorptiometry to measure the BMD of the lumbar spine (L_I-L_IV), femoral neck (FN) and total hip (TH), routine blood chemistry, measurement of C-reactive protein (CRP), rheumatoid factor, cyclic citrullinated peptide antibodies (CCPA), parathyroid hormone (PTH), vitamin D₃, myostatin, follistatin, interleukin-6 (IL-6), IL-6 receptors, insulin-like growth factor 1, adiponectin, leptin, fibroblast growth factor 23, and tumor necrosis factor SF12 were performed.

Results: PTH (β=-0.22, -0.35 and -0.30 for L_I-L_IV, FN and TH, respectively), CRP (β=-0.18, 0.23 and -0.22 for L_I-L_IV, FN and TH, respectively) and leptin (β=0.35, 0.32 and 0.42 for L_I-L_IV, FN and TH, respectively) were shown a significant association with BMD in all sites of measurement. It was independent of age, body mass index and postmenopause duration. Associations were also found between adiponectin and BMD of L_I-L_IV and TH (β=-0.36 and -0.28, respectively), CCPA and BMD of FN and TH (β=-0.21, -0.24, respectively) and IL-6 and BMD of FN (β=0.37).

Conclusion: The study of biochemical and immunological markers in women with RA demonstrated that CRP, CCPA, PTH, IL-6, adiponectin, and leptin influenced BMD.

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[类风湿性关节炎女性患者的骨质密度：免疫和生化指标之间的联系]。

目的：研究类风湿关节炎（RA）绝经后妇女的骨矿物质密度（BMD）与血清生化和免疫标记物之间的关系：研究对象包括 173 名患 RA 的妇女（年龄 61.0 [56.0; 66.0] 岁）。通过调查、双能 X 射线吸收测量法测量腰椎 (LI-LIV)、股骨颈 (FN) 和全髋 (TH) 的 BMD，常规血液化学，测量 C 反应蛋白 (CRP)、类风湿因子、环瓜氨酸肽抗体 (CCPA)、对甲状旁腺激素（PTH）、维生素 D3、肌生长因子、绒毛膜促性腺激素、白细胞介素-6（IL-6）、IL-6 受体、胰岛素样生长因子 1、脂肪连素、瘦素、成纤维细胞生长因子 23 和肿瘤坏死因子 SF12 进行了测定。结果显示在所有测量部位，PTH（β=-0.22，LI-LIV、FN 和 TH 分别为-0.35 和-0.30）、CRP（β=-0.18，LI-LIV、FN 和 TH 分别为 0.23 和-0.22）和瘦素（β=0.35，LI-LIV、FN 和 TH 分别为 0.32 和 0.42）均与 BMD 有显著关联。这与年龄、体重指数和绝经后持续时间无关。此外，还发现脂肪连素与 LI-LIV 和 TH 的 BMD（β=-0.36 和-0.28）、CCPA 与 FN 和 TH 的 BMD（β=-0.21 和-0.24）以及 IL-6 与 FN 的 BMD（β=0.37）之间存在关联：结论：对女性 RA 患者生化和免疫标记物的研究表明，CRP、CCPA、PTH、IL-6、脂肪连素和瘦素对 BMD 有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Terapevticheskii Arkhiv 医学-医学：内科

CiteScore

1.40

自引率

33.30%

发文量

171

审稿时长

3-8 weeks

期刊介绍： Терапевтический архив The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal. Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases. The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists. The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal. The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory. The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations. By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE). The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.