[Results of a randomized double-blind multicenter clinical trial of the efficacy and safety of riamilovir in the treatment of COVID-19].

Pub Date : 2024-06-03 DOI:10.26442/00403660.2024.05.202770
A U Sabitov, D A Lioznov, K V Zhdanov, E P Tikhonova, E V Esaulenko, O P Kovtun, P L Kuznetsov, P V Sorokin
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Abstract

Aim: To evaluate the efficacy and safety of riamilovir in the treatment of COVID-19 in adults.

Materials and methods: The study included 180 patients with a laboratory-confirmed diagnosis of COVID-19 which fully meet the criteria for inclusion, non-inclusion and exclusion, signed a voluntary informed consent to participate in a clinical trial.

Results: The efficacy, good tolerability and safety of the drug riamilovir in the treatment of COVID-19 have been established.

Conclusion: As a result of a multicenter randomized double-blind clinical trial, the effectiveness of the drug riamilovir for therapeutic use in patients with COVID-19 according to the 1250 mg/day scheme (250 mg capsules 5 times per day) for 10 days was established. The drug riamilovir in a daily dose of 1250 mg for 10 days does not differ in safety from placebo.

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[里亚米洛韦治疗 COVID-19 的疗效和安全性随机双盲多中心临床试验结果]。
目的:评估利拉米诺韦治疗成人COVID-19的有效性和安全性:研究纳入了180例经实验室确诊的COVID-19患者,这些患者完全符合纳入、非纳入和排除标准,并自愿签署知情同意书参与临床试验:结果:里亚米洛韦治疗 COVID-19 的疗效、良好的耐受性和安全性均已得到证实:作为一项多中心随机双盲临床试验的结果,根据1250毫克/天的方案(250毫克胶囊,每天5次),对COVID-19患者进行为期10天的治疗,确定了利拉米洛韦的疗效。与安慰剂相比,每天服用1250毫克、连续服用10天的里亚米洛韦在安全性方面没有差别。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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