{"title":"Cobalt-catalyzed chemoselective alkenylation and alkylation of C(sp3)–H bond in methyl heteroarenes","authors":"Baoying Zhu , Haitao Tian , Zhaolun Zhang , Ting Li , Lingbo Qu , Conghui Tang","doi":"10.1016/j.jcat.2024.115569","DOIUrl":null,"url":null,"abstract":"<div><p>Chemoselective synthesis allows for the generation of diverse products from identical starting materials, which is a significant strategy to build molecular diversity rapidly. By employing acceptorless dehydrogenation and borrowing hydrogen strategies, we herein report a cobalt-catalyzed chemoselective C(sp<sup>3</sup>)–H bond functionalization of methyl heteroarenes, the alkenylation and alkylation products are obtained using alcohol as the coupling partner under different reaction conditions. The scopes of both arenes and alcohols, synthetic applications, preliminary mechanistic studies, and a proposed mechanism were presented.</p></div>","PeriodicalId":346,"journal":{"name":"Journal of Catalysis","volume":null,"pages":null},"PeriodicalIF":6.5000,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Catalysis","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0021951724002823","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Chemoselective synthesis allows for the generation of diverse products from identical starting materials, which is a significant strategy to build molecular diversity rapidly. By employing acceptorless dehydrogenation and borrowing hydrogen strategies, we herein report a cobalt-catalyzed chemoselective C(sp3)–H bond functionalization of methyl heteroarenes, the alkenylation and alkylation products are obtained using alcohol as the coupling partner under different reaction conditions. The scopes of both arenes and alcohols, synthetic applications, preliminary mechanistic studies, and a proposed mechanism were presented.
期刊介绍：
The Journal of Catalysis publishes scholarly articles on both heterogeneous and homogeneous catalysis, covering a wide range of chemical transformations. These include various types of catalysis, such as those mediated by photons, plasmons, and electrons. The focus of the studies is to understand the relationship between catalytic function and the underlying chemical properties of surfaces and metal complexes.
The articles in the journal offer innovative concepts and explore the synthesis and kinetics of inorganic solids and homogeneous complexes. Furthermore, they discuss spectroscopic techniques for characterizing catalysts, investigate the interaction of probes and reacting species with catalysts, and employ theoretical methods.
The research presented in the journal should have direct relevance to the field of catalytic processes, addressing either fundamental aspects or applications of catalysis.
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