Ferritinophagy and Ferroptosis in Cerebral Ischemia Reperfusion Injury

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Neurochemical Research Pub Date : 2024-06-04 DOI:10.1007/s11064-024-04161-5

Xiaoyue Liu, Canming Xie, Yao Wang, Jing Xiang, Litong Chen, Jia Yuan, Chutao Chen, Haomei Tian

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Abstract

Cerebral ischemia–reperfusion injury (CIRI) is the second leading cause of death worldwide, posing a huge risk to human life and health. Therefore, investigating the pathogenesis underlying CIRI and developing effective treatments are essential. Ferroptosis is an iron-dependent mode of cell death, which is caused by disorders in iron metabolism and lipid peroxidation. Previous studies demonstrated that ferroptosis is also a form of autophagic cell death, and nuclear receptor coactivator 4(NCOA4) mediated ferritinophagy was found to regulate ferroptosis by interfering with iron metabolism. Ferritinophagy and ferroptosis are important pathogenic mechanisms in CIRI. This review mainly summarizes the link and regulation between ferritinophagy and ferroptosis and further discusses their mechanisms in CIRI. In addition, the potential treatment methods targeting ferritinophagy and ferroptosis for CIRI are presented, providing new ideas for the prevention and treatment of clinical CIRI in the future.

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脑缺血再灌注损伤中的噬铁蛋白和铁变态反应

脑缺血再灌注损伤（CIRI）是全球第二大死亡原因，对人类的生命和健康构成巨大威胁。因此，研究 CIRI 的发病机制并开发有效的治疗方法至关重要。铁变态反应是一种铁依赖性细胞死亡模式，由铁代谢紊乱和脂质过氧化引起。先前的研究表明，铁嗜酸也是细胞自噬死亡的一种形式，核受体辅激活子4（NCOA4）介导的铁蛋白吞噬被发现可通过干扰铁代谢来调节铁嗜酸。噬铁蛋白和铁突变是 CIRI 的重要致病机制。本综述主要总结了噬铁蛋白和嗜铁细胞之间的联系和调控，并进一步探讨了它们在 CIRI 中的作用机制。此外，还介绍了针对 CIRI 的嗜铁蛋白和嗜铁细胞的潜在治疗方法，为今后临床 CIRI 的预防和治疗提供了新思路。

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来源期刊

Neurochemical Research 医学-神经科学

CiteScore

7.70

自引率

2.30%

发文量

320

审稿时长

6 months

期刊介绍： Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.