Evaluation of intravitreal injections as a risk factor for capsular rupture during cataract surgery.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-06-02 DOI:10.1016/j.jcjo.2024.05.012

Thomas Falb, Christoph Singer, Magdalena Holter, Lisa Eder, Manuel Grosspötzl, Martin Weger, Ewald Lindner, Andrea Berghold, Christoph Mayer-Xanthaki, Anton Haas, Andreas Wedrich

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Abstract

Objective: To determine whether previous intravitreal injections are an independent risk factor for posterior capsular rupture (PCR) during cataract surgery after adjusting for known risk factors.

Design: Single-centre medical records analysis of a population-based cohort at a university-based referral centre. A retrospective cohort study has been conducted with inclusion of cataract surgeries done from January 1, 2005 to December 31, 2020 at the Department of Ophthalmology, Medical University of Graz, Austria.

Participants: All consecutive cataract surgeries done in patients of at least 18 years of age from January 1, 2005 to December 31, 2020 have been included.

Methods: Association between previous intravitreal injections and PCR rates has been analysed through univariable and multivariable generalized estimating equations (GEE). Other investigated risk factors were age, combined surgery, pseudoexfoliation, surgeon's experience, and type of cataract surgery.

Results: A statistically significant higher rate of posterior capsular rupture during cataract surgery has been found in patients with previous intravitreal therapy compared with patients with no history of intravitreal therapy (OR 1.27, 95% CI 1.10-1.46, p = 0.008). However, after adjusting for confounding risk factors, no statistically significant effect was seen (OR 1.04, 95% CI 0.89-1.21, p = 0.664).

Conclusion: We found no association between history of intravitreal injections and PCR during cataract surgery after adjusting for known risk factors. Further studies upon interactions between history of intravitreal injections and known risk factors for PCR, especially pseudoexfoliation, are needed.

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评估作为白内障手术中囊膜破裂风险因素的玻璃体内注射。

目的：确定在调整已知风险因素后，先前的玻璃体内注射是否是白内障手术后囊破裂（PCR）的独立风险因素：在对已知风险因素进行调整后，确定之前的玻璃体内注射是否是白内障手术中后囊破裂（PCR）的独立风险因素：设计：对一家大学转诊中心的人群队列进行单中心病历分析。奥地利格拉茨医科大学眼科系对 2005 年 1 月 1 日至 2020 年 12 月 31 日期间进行的白内障手术进行了回顾性队列研究：方法：将 2005 年 1 月 1 日至 2020 年 12 月 31 日期间为至少 18 岁患者进行的所有连续白内障手术纳入研究范围：方法：通过单变量和多变量广义估计方程（GEE）分析了既往玻璃体内注射与 PCR 发生率之间的关系。其他调查的风险因素包括年龄、合并手术、假性角膜剥脱、外科医生的经验以及白内障手术的类型：结果：与无玻璃体内治疗史的患者相比，曾接受过玻璃体内治疗的患者在白内障手术过程中发生后囊破裂的比例明显更高（OR 1.27，95% CI 1.10-1.46，P = 0.008）。然而，在对混杂的风险因素进行调整后，并未发现有统计学意义的影响（OR 1.04，95% CI 0.89-1.21，p = 0.664）：结论：在对已知风险因素进行调整后，我们发现白内障手术中的玻璃体内注射史与 PCR 之间没有关联。需要进一步研究玻璃体内注射史与 PCR（尤其是假性角膜外翻）已知风险因素之间的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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