Astrid De Boeck, Erik Nohr, Soufiane El-Hallani, Prafull Ghatage, Cheng Han Lee, Martin Köbel
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引用次数: 0
Abstract
The molecular subtype classification of endometrial carcinomas has conceptually changed our approach to this disease. However, open questions remain about how to integrate certain histotype diagnoses with the molecular subtype. We report 2 cases with morphologic suspicion for endometrial carcinosarcoma, that still fell short of the essential criteria for diagnosing carcinosarcoma. On subsequent molecular testing pathogenic POLE mutations were detected and a descriptive diagnosis of endometrial endometrioid carcinomas, low-grade with a homologous sarcoma component was rendered. This challenges the existence of POLE-mutated "carcinosarcoma."
子宫内膜癌的分子亚型分类从概念上改变了我们治疗这种疾病的方法。然而，如何将某些组织型诊断与分子亚型结合起来仍是一个未决问题。我们报告了 2 例形态学上怀疑为子宫内膜癌肉瘤的病例，但仍未达到诊断癌肉瘤的基本标准。在随后的分子检测中发现了致病性 POLE 突变，并做出了子宫内膜样癌、低级别子宫内膜样癌和同源肉瘤成分的描述性诊断。这对存在 POLE 突变的 "癌肉瘤 "提出了质疑。
期刊介绍：
International Journal of Gynecological Pathology is the official journal of the International Society of Gynecological Pathologists (ISGyP), and provides complete and timely coverage of advances in the understanding and management of gynecological disease. Emphasis is placed on investigations in the field of anatomic pathology. Articles devoted to experimental or animal pathology clearly relevant to an understanding of human disease are published, as are pathological and clinicopathological studies and individual case reports that offer new insights.
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