Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives.

IF 16.7 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Military Medical Research Pub Date : 2024-06-04 DOI:10.1186/s40779-024-00535-6
Xian-Bin Zhang, Yi-Bao Fan, Rui Jing, Mikiyas Amare Getu, Wan-Ying Chen, Wei Zhang, Hong-Xia Dong, Tikam Chand Dakal, Akhtar Hayat, Hua-Jun Cai, Milad Ashrafizadeh, A M Abd El-Aty, Ahmet Hacimuftuoglu, Peng Liu, Tian-Feng Li, Gautam Sethi, Kwang Seok Ahn, Yavuz Nuri Ertas, Min-Jiang Chen, Jian-Song Ji, Li Ma, Peng Gong
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Abstract

Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common subtype of NENs. Historically, GEP-NENs have been regarded as infrequent and slow-growing malignancies; however, recent data have demonstrated that the worldwide prevalence and incidence of GEP-NENs have increased exponentially over the last three decades. In addition, an increasing number of studies have proven that GEP-NENs result in a limited life expectancy. These findings suggested that the natural biology of GEP-NENs is more aggressive than commonly assumed. Therefore, there is an urgent need for advanced researches focusing on the diagnosis and management of patients with GEP-NENs. In this review, we have summarized the limitations and recent advancements in our comprehension of the epidemiology, clinical presentations, pathology, molecular biology, diagnosis, and treatment of GEP-NETs to identify factors contributing to delays in diagnosis and timely treatment of these patients.

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胃肠胰神经内分泌肿瘤:当前发展、挑战和临床前景。
神经内分泌肿瘤(NENs)是神经内分泌系统分泌细胞产生的高度异质性和潜在恶性肿瘤。胃肠胰神经内分泌肿瘤(GEP-NENs)是神经内分泌肿瘤中最常见的亚型。一直以来,GEP-NENs 被认为是不常见且生长缓慢的恶性肿瘤;然而,最近的数据表明,在过去的三十年中,GEP-NENs 的全球流行率和发病率呈指数增长。此外,越来越多的研究证明,GEP-NENs 会导致患者寿命缩短。这些研究结果表明,GEP-NENs 的自然生物学特性比通常认为的更具侵袭性。因此,亟需对 GEP-NENs 患者的诊断和治疗进行深入研究。在这篇综述中,我们总结了我们在了解 GEP-NET 的流行病学、临床表现、病理学、分子生物学、诊断和治疗方面的局限性和最新进展,以找出导致这些患者延误诊断和及时治疗的因素。
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来源期刊
Military Medical Research
Military Medical Research Medicine-General Medicine
CiteScore
38.40
自引率
2.80%
发文量
485
审稿时长
8 weeks
期刊介绍: Military Medical Research is an open-access, peer-reviewed journal that aims to share the most up-to-date evidence and innovative discoveries in a wide range of fields, including basic and clinical sciences, translational research, precision medicine, emerging interdisciplinary subjects, and advanced technologies. Our primary focus is on modern military medicine; however, we also encourage submissions from other related areas. This includes, but is not limited to, basic medical research with the potential for translation into practice, as well as clinical research that could impact medical care both in times of warfare and during peacetime military operations.
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