Access to mifepristone, misoprostol, and contraceptive medicines in eight countries in the Eastern Mediterranean Region: descriptive analyses of country-level assessments.

IF 3.6 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Reproductive Health Pub Date : 2024-06-04 DOI:10.1186/s12978-024-01805-1
Mohamed Afifi, Nilmini Hemachandra, Qais Sikandar, Rana Hajjeh, Ulrika Rehnström Loi, Laurence Läser, Dima Qato, Zahir Sidiqui Abdul, Paata Chikvaidze, Raghad Abdul Redha Abbas, Khalid Al-Kinani, Hanan Hasan, Faysal El-Kak, Alissar Rady, Omelkheir Brngali, Mohamed Hashem, Rachid Bezad, Cheikh Amine, Hachri Hafid, Sabeen Afzal, Raza Zaidi, Ellen Thom, Qudsia Uzma, Hadeel Al-Masri, Zakri Abu Qamar, Buthaina Ghanem, Itimad Abu Ward, Ali Nashat Shaar, Ubah Farah, Yusuf Omar Mohamed, Al-Umra Umar, Maha Eladawy
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Abstract

Background: Despite their importance in reducing maternal mortality, information on access to Mifepristone, Misoprostol, and contraceptive medicines in the Eastern Mediterranean Region is limited.

Methods: A standardized assessment tool measuring access to Mifepristone, Misoprostol, and contraceptive medicines included in the WHO essential medicines list (EML) was implemented in eight countries in the Eastern Mediterranean Region (Afghanistan, Iraq, Lebanon, Libya, Morocco, Palestine, Pakistan, and Somalia) between 2020-2021. The assessment focused on five access measures: 1) the inclusion of medicines in national family planning guidelines; 2) inclusion of medicines in comprehensive abortion care guidelines; 3) inclusion of medicines on national essential medicines lists; 4) medicines registration; and 5) procurement and forecasting of Mifepristone, Misoprostol, and contraceptive medicines. A descriptive analysis of findings from these eight national assessments was conducted.

Results: Only Lebanon and Pakistan included all 12 contraceptives that are enlisted in the WHO-EML within their national family planning guidelines. Only Afghanistan and Lebanon included mifepristone and mifepristone-misoprostol combination in post-abortion care guidelines, but these medicines were not included in their national EMLs. Libya and Somalia lacked a national regulatory authority for medicines registration. Most contraceptives included on the national EMLs for Lebanon, Morocco and Pakistan were registered. Misoprostol was included on the EMLs-and registered-in six countries (Afghanistan, Iraq, Lebanon, Morocco, Palestine, and Pakistan). However, only three countries procured misoprostol (Iraq, Morocco, and Somalia).

Conclusion: These findings can guide efforts aimed at improving the availability of Mifepristone, Misoprostol, and contraceptive medicines in the Eastern Mediterranean Region. Opportunities include expanding national EMLs to include more options for Mifepristone, Misoprostol, and contraceptive medicines and strengthening the registration and procurement systems to ensure these medicines' availability were permitted under national law and where culturally acceptable.

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东地中海地区八个国家获得米非司酮、米索前列醇和避孕药物的情况:国家级评估的描述性分析。
背景:尽管米非司酮、米索前列醇和避孕药物在降低孕产妇死亡率方面非常重要,但有关东地中海地区获取这些药物的信息却非常有限:方法:2020-2021 年间,在东地中海地区的八个国家(阿富汗、伊拉克、黎巴嫩、利比亚、摩洛哥、巴勒斯坦、巴基斯坦和索马里)实施了一项标准化评估工具,以衡量世界卫生组织基本药物清单(EML)中所列的米非司酮、米索前列醇和避孕药物的可及性。评估的重点是五项获取措施:1) 将药品纳入国家计划生育指南;2) 将药品纳入综合流产护理指南;3) 将药品纳入国家基本药品清单;4) 药品注册;5) 米非司酮、米索前列醇和避孕药物的采购和预测。对这八个国家的评估结果进行了描述性分析:结果:只有黎巴嫩和巴基斯坦将世界卫生组织 EML 中列出的全部 12 种避孕药具纳入了其国家计划生育指导方针。只有阿富汗和黎巴嫩将米非司酮和米非司酮-米索前列醇复方制剂纳入了堕胎后护理指南,但这些药物未被纳入其国家 EML。利比亚和索马里没有负责药品注册的国家监管机构。黎巴嫩、摩洛哥和巴基斯坦的国家 EML 中包含的大多数避孕药具均已注册。米索前列醇被列入六个国家(阿富汗、伊拉克、黎巴嫩、摩洛哥、巴勒斯坦和巴基斯坦)的 EML 并进行了注册。然而,只有三个国家采购了米索前列醇(伊拉克、摩洛哥和索马里):这些发现可以为东地中海地区改善米非司酮、米索前列醇和避孕药物的供应提供指导。机会包括扩大国家 EML,以纳入更多的米非司酮、米索前列醇和避孕药物选择,并加强登记和采购系统,以确保在国家法律允许和文化上可接受的情况下提供这些药物。
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来源期刊
Reproductive Health
Reproductive Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
6.00
自引率
5.90%
发文量
220
审稿时长
>12 weeks
期刊介绍: Reproductive Health focuses on all aspects of human reproduction. The journal includes sections dedicated to adolescent health, female fertility and midwifery and all content is open access. Reproductive health is defined as a state of physical, mental, and social well-being in all matters relating to the reproductive system, at all stages of life. Good reproductive health implies that people are able to have a satisfying and safe sex life, the capability to reproduce and the freedom to decide if, when, and how often to do so. Men and women should be informed about and have access to safe, effective, affordable, and acceptable methods of family planning of their choice, and the right to appropriate health-care services that enable women to safely go through pregnancy and childbirth.
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