The Preparation of Iron-Based Scaffolds with an Antibacterial Coating Based on Polylactic Acid and Vancomycin

IF 0.5 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY Inorganic Materials: Applied Research Pub Date : 2024-06-03 DOI:10.1134/s207511332470028x
A. S. Lozhkomoev, S. O. Kazantsev, O. V. Bakina, A. S. Buyakov, E. I. Senkina, M. G. Krinitcyn, V. A. Ivanyuk, A. F. Sharipova, M. I. Lerner
{"title":"The Preparation of Iron-Based Scaffolds with an Antibacterial Coating Based on Polylactic Acid and Vancomycin","authors":"A. S. Lozhkomoev, S. O. Kazantsev, O. V. Bakina, A. S. Buyakov, E. I. Senkina, M. G. Krinitcyn, V. A. Ivanyuk, A. F. Sharipova, M. I. Lerner","doi":"10.1134/s207511332470028x","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract—</h3><p>A method for obtaining iron scaffolds with porosity of about 70% with the use of a Fe nanopowder with an average size of 68 ± 2 nm and modified with vancomycin to impart antibacterial properties to the material is described. Studies of the structure and composition of the scaffolds and mechanical characteristics that demonstrate high values of the ultimate strength of the samples (about 15 MPa) are carried out. The modification of the surface of the scaffolds with polylactic acid leads to an increase in the ultimate strength by 40% and overall smoothing of the stress–strain curve. It is shown that the introduction of vancomycin into the polymer makes it possible to obtain an antibacterial coating on the surface of the scaffold with prolonged release of the medicinal product.</p>","PeriodicalId":586,"journal":{"name":"Inorganic Materials: Applied Research","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganic Materials: Applied Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s207511332470028x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Abstract—

A method for obtaining iron scaffolds with porosity of about 70% with the use of a Fe nanopowder with an average size of 68 ± 2 nm and modified with vancomycin to impart antibacterial properties to the material is described. Studies of the structure and composition of the scaffolds and mechanical characteristics that demonstrate high values of the ultimate strength of the samples (about 15 MPa) are carried out. The modification of the surface of the scaffolds with polylactic acid leads to an increase in the ultimate strength by 40% and overall smoothing of the stress–strain curve. It is shown that the introduction of vancomycin into the polymer makes it possible to obtain an antibacterial coating on the surface of the scaffold with prolonged release of the medicinal product.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
制备具有基于聚乳酸和万古霉素的抗菌涂层的铁基支架
摘要 描述了一种利用平均尺寸为 68±2 纳米的铁纳米粉体获得孔隙率约为 70% 的铁支架的方法,该方法利用万古霉素对铁纳米粉体进行改性,以赋予材料抗菌特性。对支架的结构和组成以及机械特性进行了研究,结果表明样品的极限强度值很高(约 15 兆帕)。用聚乳酸对支架表面进行改性后,极限强度提高了 40%,应力-应变曲线总体上变得平滑。研究表明,在聚合物中加入万古霉素可以在支架表面形成抗菌涂层,延长药物的释放时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Inorganic Materials: Applied Research
Inorganic Materials: Applied Research Engineering-Engineering (all)
CiteScore
0.90
自引率
0.00%
发文量
199
期刊介绍: Inorganic Materials: Applied Research  contains translations of research articles devoted to applied aspects of inorganic materials. Best articles are selected from four Russian periodicals: Materialovedenie, Perspektivnye Materialy, Fizika i Khimiya Obrabotki Materialov, and Voprosy Materialovedeniya  and translated into English. The journal reports recent achievements in materials science: physical and chemical bases of materials science; effects of synergism in composite materials; computer simulations; creation of new materials (including carbon-based materials and ceramics, semiconductors, superconductors, composite materials, polymers, materials for nuclear engineering, materials for aircraft and space engineering, materials for quantum electronics, materials for electronics and optoelectronics, materials for nuclear and thermonuclear power engineering, radiation-hardened materials, materials for use in medicine, etc.); analytical techniques; structure–property relationships; nanostructures and nanotechnologies; advanced technologies; use of hydrogen in structural materials; and economic and environmental issues. The journal also considers engineering issues of materials processing with plasma, high-gradient crystallization, laser technology, and ultrasonic technology. Currently the journal does not accept direct submissions, but submissions to one of the source journals is possible.
期刊最新文献
Influence of Aluminum Hydroxide Concentration in a Liquid Photocuring Resin on the Properties of Cured Specimens FeZrN Films: Static and Microwave Magnetic Properties The Preparation of Iron-Based Scaffolds with an Antibacterial Coating Based on Polylactic Acid and Vancomycin P–T–x Phase Diagram of Al–Ba System Structural Modification of Fine Powders of Overburden Rocks of Saponite-Containing Bentonite Clay
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1