A. F. Arutuynyan, M. S. Aksenova, A. A. Kostyukov, A. A. Stomakhin, D. N. Kaluzhny, A. L. Zhuze
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引用次数: 0
Abstract
Using a computer modeling approach, we proposed a structure for a potential GC-specific DNA ligand, which could form a complex with DNA in the minor groove similar to that formed by Hoechst 33258 at DNA AT-enriched sites. According to this model, MBoz2A, a bisbenzoxazole ligand, was synthesized. The results of spectrophotometric methods supported the complex formation of the compound under study with DNA differing in the nucleotide composition.
摘要 利用计算机建模方法，我们提出了一种潜在的 GC 特异性 DNA 配体的结构，这种配体可与 DNA 在小沟中形成复合物，类似于 Hoechst 33258 在 DNA AT 富集位点上形成的复合物。根据这一模型，合成了双苯并恶唑配体 MBoz2A。分光光度法的结果表明，所研究的化合物与核苷酸组成不同的 DNA 形成了复合物。
期刊介绍：
Molecular Biology is an international peer reviewed journal that covers a wide scope of problems in molecular, cell and computational biology including genomics, proteomics, bioinformatics, molecular virology and immunology, molecular development biology, molecular evolution and related areals. Molecular Biology publishes reviews, experimental and theoretical works. Every year, the journal publishes special issues devoted to most rapidly developing branches of physical-chemical biology and to the most outstanding scientists.
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