The antisickling agent, 5-hydroxymethyl-2-furfural: Other potential pharmacological applications

IF 10.9 1区 医学 Q1 CHEMISTRY, MEDICINAL Medicinal Research Reviews Pub Date : 2024-06-06 DOI:10.1002/med.22062
Piyusha P. Pagare, Mina McGinn, Mohini S. Ghatge, Vibha Shekhar, Rana T. Alhashimi, B. Daniel Pierce, Osheiza Abdulmalik, Yan Zhang, Martin K. Safo
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Abstract

For the last two decades, the aromatic aldehyde 5-hydroxymethyl-furfural (5-HMF) has been the subject of several investigations for its pharmacologic potential. In 2004, the Safo group reported that 5-HMF has potent antisickling activity by targeting and ameliorating the primary pathophysiology of hypoxia-induced sickling of erythrocytes (red blood cells [RBC]). Following the encouraging outcome of the preclinical and phase I/II clinical studies of 5-HMF for the treatment of sickle cell disease (SCD), there have been multiple studies suggesting 5-HMF has several other biological or pharmacologic activities, including anti-allergic, antioxidant, anti-hypoxic, anti-ischemic, cognitive improvement, anti-tyrosinase, anti-proliferation, cytoprotective, and anti-inflammatory activities. The wide range of its effects makes 5-HMF a potential candidate for treating a variety of diseases including cognitive disorders, gout, allergic disorders, anemia, hypoxia, cancers, ischemia, hemorrhagic shock, liver fibrosis, and oxidative injury. Several of these therapeutic claims are currently under investigation and, while promising, vary in terms of the strength of their evidence. This review presents the research regarding the therapeutic potential of 5-HMF in addition to its sources, physicochemical properties, safety, absorption, distribution, metabolism, and excretion (ADME) profiles.

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抗ickling剂,5-羟甲基-2-糠醛:其他潜在的药理应用。
过去二十年来,芳香醛 5-羟甲基糠醛(5-HMF)的药理潜力一直是多项研究的主题。2004 年,Safo 研究小组报告称,5-HMF 针对并改善缺氧诱发红细胞(红血球 [RBC])镰状化的主要病理生理现象,具有强效的抗镰状化活性。继 5-HMF 治疗镰状细胞病(SCD)的临床前研究和 I/II 期临床研究取得令人鼓舞的成果之后,又有多项研究表明 5-HMF 还具有其他多种生物或药理活性,包括抗过敏、抗氧化、抗缺氧、抗缺血、改善认知、抗酪氨酸酶、抗增殖、细胞保护和抗炎活性。5-HMF 的广泛作用使其成为治疗多种疾病的潜在候选药物,包括认知障碍、痛风、过敏性疾病、贫血、缺氧、癌症、缺血、失血性休克、肝纤维化和氧化损伤。目前正在对其中几种治疗方法进行调查,虽然这些方法很有前景,但其证据的力度却各不相同。本综述介绍了有关 5-HMF 治疗潜力的研究,以及其来源、理化性质、安全性、吸收、分布、代谢和排泄(ADME)概况。
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来源期刊
CiteScore
29.30
自引率
0.00%
发文量
52
审稿时长
2 months
期刊介绍: Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.
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