Evaluation of InBios Scrub Typhus Detect IgM Rapid Test in Acute Fever Cases from Southwest and East India.

IF 0.8 4区医学 Q4 INFECTIOUS DISEASES Journal of Vector Borne Diseases Pub Date : 2024-05-20 DOI:10.4103/JVBD.JVBD_73_22

Punekar Madhura, Anup Jayaram, Prasad Varamballi, Dsa Oliver, Sasidharanpillai Sabeena

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Abstract

Background objectives: Scrub typhus is clinically undifferentiated from other aetiologies for acute febrile illness such as enteric fever, dengue, malaria, and leptospirosis. Rapid ELISA tests are being used as an alternative to immunofluorescence assay in tropical countries.

Methods: In this study, we compared and evaluated commercially available InBios Scrub Typhus Detect IgM Rapid Test (USA) for diagnosing human scrub typhus infection using archived and prospectively collected samples against the reference standard, InBios Scrub Typhus Detect IgM ELISA (USA).

Results: The data analysis of archived samples on rapid test revealed a moderate sensitivity of 53.92% and a specificity of 100%. Meanwhile, prospective serum samples demonstrated higher sensitivity and specificity of 96.4% and 94.6%, respectively.

Interpretation conclusion: The InBios Scrub Typhus Detect IgM rapid test can be a good point-of-care assay during surveillance, outbreak investigations, and case identification.

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在印度西南部和东部的急性发热病例中评估 InBios 恙虫病检测 IgM 快速检测仪。

背景目标：恙虫病与其他急性发热性疾病（如肠热、登革热、疟疾和钩端螺旋体病）在临床上没有区别。在热带国家，快速 ELISA 检测法正被用作免疫荧光检测法的替代方法：在这项研究中，我们使用存档样本和前瞻性采集样本，将市售的 InBios Scrub Typhus Detect IgM 快速检测试剂盒（美国）与参考标准 InBios Scrub Typhus Detect IgM ELISA（美国）进行比较和评估，以诊断人类恙虫病感染：对存档样本的快速检测数据分析显示，灵敏度为 53.92%，特异性为 100%。同时，前瞻性血清样本的灵敏度和特异性较高，分别为 96.4% 和 94.6%：InBios恙虫病检测IgM快速检测试剂盒可作为监测、疫情调查和病例鉴定中的一种良好的床旁检测方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vector Borne Diseases INFECTIOUS DISEASES-PARASITOLOGY

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： National Institute of Malaria Research on behalf of Indian Council of Medical Research (ICMR) publishes the Journal of Vector Borne Diseases. This Journal was earlier published as the Indian Journal of Malariology, a peer reviewed and open access biomedical journal in the field of vector borne diseases. The Journal publishes review articles, original research articles, short research communications, case reports of prime importance, letters to the editor in the field of vector borne diseases and their control.