Epstein-Barr virus as promoter of Lemierre syndrome: systematic literature review.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-10-01 Epub Date: 2024-06-05 DOI:10.1007/s00405-024-08767-x

Alessia A Delcò, Sara M M A Montorfani, Renato Gualtieri, Sebastiano A G Lava, Gregorio P Milani, Mario G Bianchetti, Gabriel Bronz, Pietro B Faré, Lisa Kottanattu

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Abstract

Purpose: To investigate a possible link between acute Epstein-Barr virus infection and Lemierre syndrome, a rare yet life-threatening infection.

Methods: A systematic review was conducted adhering to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Diagnosis criteria for Lemierre syndrome were established, and data extraction encompassed demographic data, clinical, and laboratory information.

Results: Out of 985 initially identified papers, 132 articles were selected for the final analysis. They reported on 151 cases of Lemierre syndrome (76 female and 75 male patients with a median of 18 years) alongside interpretable results for Epstein-Barr virus serology. Among these, 38 cases (25%) tested positive for acute Epstein-Barr virus serology. There were no differences in terms of age, sex, or Fusobacterium presence between the serologically positive and negative groups. Conversely, instances of cervical thrombophlebitis and pulmonary complications were significantly higher (P = 0.0001) among those testing negative. The disease course was lethal in one case for each of the two groups.

Conclusions: This analysis provides evidence of an association between acute Epstein-Barr virus infection and Lemierre syndrome. Raising awareness of this link within the medical community is desirable.

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Epstein-Barr 病毒是莱米埃尔综合征的促发因子：系统文献综述。

目的：研究急性爱泼斯坦-巴氏病毒感染与莱米埃尔综合征（一种罕见但危及生命的感染）之间可能存在的联系：方法：根据《2020 年系统综述和元分析首选报告项目》指南进行了系统综述。确定了莱米埃尔综合征的诊断标准，数据提取包括人口统计学数据、临床和实验室信息：结果：在 985 篇初步确定的论文中，有 132 篇文章被选中进行最终分析。这些文章报告了 151 例莱米埃尔综合征病例（76 例女性和 75 例男性患者，中位年龄为 18 岁）以及可解释的 Epstein-Barr 病毒血清学检测结果。其中，38 例（25%）急性 Epstein-Barr 病毒血清学检测呈阳性。血清学阳性组和阴性组在年龄、性别或镰刀菌存在方面没有差异。相反，血清检测呈阴性的患者出现宫颈血栓性静脉炎和肺部并发症的几率明显更高（P = 0.0001）。两组患者中各有一例病死：这项分析提供了急性 Epstein-Barr 病毒感染与莱米埃尔综合征之间存在关联的证据。希望能提高医学界对这一联系的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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