A case of diagnostic uncertainty: High-grade melanocytoma versus balloon cell melanoma in a pediatric patient

IF 1.6 4区 医学 Q3 DERMATOLOGY Journal of Cutaneous Pathology Pub Date : 2024-06-04 DOI:10.1111/cup.14664
Serena Shimshak MD, Olayemi Sokumbi MD, Ruifeng Guo MD, PhD, Dawn Marie R. Davis MD, Katherine B. Geiersbach MD, Nneka I. Comfere MD
{"title":"A case of diagnostic uncertainty: High-grade melanocytoma versus balloon cell melanoma in a pediatric patient","authors":"Serena Shimshak MD,&nbsp;Olayemi Sokumbi MD,&nbsp;Ruifeng Guo MD, PhD,&nbsp;Dawn Marie R. Davis MD,&nbsp;Katherine B. Geiersbach MD,&nbsp;Nneka I. Comfere MD","doi":"10.1111/cup.14664","DOIUrl":null,"url":null,"abstract":"<p>An 11-year-old female was referred from an outside institution after a diagnostic biopsy and subsequent excision of a progressively enlarging reddish-brown nodule demonstrated features concerning for a balloon cell nevus with severe atypia versus a high-grade melanocytoma. Upon review of the initial biopsy specimen and molecular data, we favored the diagnosis to be consistent with a high-grade melanocytoma with balloon cell changes while considering the possibility of balloon cell melanoma due to concerning histopathologic and genetic abnormalities. In this case study, we discuss critical diagnostic considerations in this rare pediatric case and highlight important pathologic and clinical features of melanocytomas and balloon cell melanoma.</p>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cutaneous Pathology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cup.14664","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

An 11-year-old female was referred from an outside institution after a diagnostic biopsy and subsequent excision of a progressively enlarging reddish-brown nodule demonstrated features concerning for a balloon cell nevus with severe atypia versus a high-grade melanocytoma. Upon review of the initial biopsy specimen and molecular data, we favored the diagnosis to be consistent with a high-grade melanocytoma with balloon cell changes while considering the possibility of balloon cell melanoma due to concerning histopathologic and genetic abnormalities. In this case study, we discuss critical diagnostic considerations in this rare pediatric case and highlight important pathologic and clinical features of melanocytomas and balloon cell melanoma.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
一例诊断不明确的病例:一名儿科患者的高级别黑色素细胞瘤与气球细胞黑色素瘤。
一名 11 岁的女性患者从外院转来,她的红褐色结节逐渐增大,诊断性活组织检查和随后的切除术显示,该结节具有气球细胞痣和高级别黑色素细胞瘤的特征,且严重不典型。在对最初的活检标本和分子数据进行复查后,我们认为诊断结果与伴有气球细胞变化的高级别黑色素细胞瘤一致,同时考虑到组织病理学和基因异常导致的气球细胞黑色素瘤的可能性。在本病例研究中,我们讨论了这一罕见儿科病例的关键诊断因素,并强调了黑色素细胞瘤和气球细胞黑色素瘤的重要病理和临床特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
期刊最新文献
Martin C. Mihm Jr: Remembrances of a great physician, charismatic person, and good friend Ancillary immunohistochemistry testing for loss of p16 in melanoma: A systematic review and meta‐analysis of diagnostic accuracy studies Issue Information Mutational profile of the KIT gene and its heterogeneity in primary and metastatic melanomas. The association of interleukin-36 staining intensity with histopathologic findings of eosinophil count and spongiosis in patients with psoriasis: A secondary analysis of a retrospective immunohistochemical and chart review pilot study.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1