Cancer and sepsis: future challenges for long-term outcome.

IF 3.5 3区医学 Q1 CRITICAL CARE MEDICINE Current Opinion in Critical Care Pub Date : 2024-10-01 Epub Date: 2024-05-31 DOI:10.1097/MCC.0000000000001173

Antoine Bianchi, Djamel Mokart, Marc Leone

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Abstract

Purpose of review: The purpose of this review is to investigate the long-term outcomes of cancer patients who experience sepsis or septic shock.

Recent findings: Sepsis is a frequent cause of ICU admission in cancer patients, accounting for approximately 15% of such cases. Short-term mortality rates among these patients vary widely across studies, but they are consistently found to be slightly higher than those of noncancer patients. However, there is a lack of evidence regarding the long-term outcomes of cancer patients who have experienced sepsis or septic shock. The few available studies have reported relatively high mortality rates, reaching around 80% in a few cohort studies. Although several observational studies have noted a decrease in 1-year mortality rates over time, observational data also suggest that sepsis may increase the risk of cancer in the long run.

Summary: As cancer is becoming a chronic disease, there is an urgent need for studies on the quality of life of cancer patients who have experienced sepsis. The relationship between sepsis and cancer extends beyond its impact on the progression of cancer, as sepsis might also contribute to the development of cancer.

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癌症与败血症：长期疗效的未来挑战。

综述目的：本综述旨在研究发生败血症或脓毒性休克的癌症患者的长期预后：脓毒症是癌症患者入住重症监护病房的常见原因，约占此类病例的 15%。不同研究发现，这些患者的短期死亡率差异很大，但始终略高于非癌症患者。然而，目前还缺乏有关经历过败血症或脓毒性休克的癌症患者长期预后的证据。现有的几项研究都报告了相对较高的死亡率，在几项队列研究中达到了 80% 左右。尽管一些观察性研究指出，随着时间的推移，1 年期死亡率有所下降，但观察性数据也表明，从长远来看，败血症可能会增加患癌症的风险。摘要：由于癌症正在成为一种慢性疾病，因此迫切需要对经历过败血症的癌症患者的生活质量进行研究。脓毒症与癌症之间的关系不仅仅是对癌症进展的影响，因为脓毒症还可能导致癌症的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Critical Care 医学-危重病医学

CiteScore

5.90

自引率

3.00%

发文量

172

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Critical Care delivers a broad-based perspective on the most recent and most exciting developments in critical care from across the world. Published bimonthly and featuring thirteen key topics – including the respiratory system, neuroscience, trauma and infectious diseases – the journal’s renowned team of guest editors ensure a balanced, expert assessment of the recently published literature in each respective field with insightful editorials and on-the-mark invited reviews.

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