WNT Signaling Cascade Proteins and LRP6 in the Formation of Various Types of Coronary Lesions in Patients With Coronary Artery Disease.

IF 0.5 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Kardiologiya Pub Date : 2024-05-31 DOI:10.18087/cardio.2024.5.n2626

Yu N Belenkov, A O Iusupova, O A Slepova, N N Pakhtusov, L V Popova, A S Lishuta, A V Krivova, N V Khabarova, M Yu Abidaev, E V Privalova

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Abstract

Aim: Assessment of WNT1, WNT3a, and LRP6 concentrations in patients with ischemic heart disease (IHD) and obstructive and non-obstructive coronary artery (CA) disease.

Material and methods: This cross-sectional observational study included 50 IHD patients (verified by coronary angiography, CAG), of which 25 (50%) were men, mean age 64.9±8.1 years; 20 patients had non-obstructive CA disease (stenosis <50%), and 30 patients had hemodynamically significant stenosis. Concentrations of WNT1, WNT3a and LRP6 were measured in all patients.

Results: The concentrations of WNT1 and WNT3a proteins were significantly higher in patients with IHD and obstructive CA disease (p < 0.001), while the concentration of LRP6 was higher in the group with non-obstructive CA disease (p = 0.016). Data analysis of the group with obstructive CA disease showed a moderate correlation between WNT1 and LRP6 (ρ=0.374; p=0.042). Correlation analysis of all groups of patients with CA disease revealed a moderate association between the concentrations of WNT1 and uric acid (ρ=0.416; p=0.007). Regression analysis showed that risk factors for the development of IHD, such as increased body mass index, age, smoking, dyslipidemia, and hypertension, did not significantly influence the type of CA disease in IHD patients. According to ROC analysis, the obstructive form of IHD was predicted by a WNT3a concentration higher than 0.155 ng/ml and a LRP6 concentration lower than 12.94 ng/ml.

Conclusion: IHD patients with non-obstructive CA disease had the greatest increase in LRP6, while patients with obstructive CA disease had significantly higher concentrations of the canonical WNT cascade proteins, WNT1 and WNT3a. According to the ROC analysis, a WNT3a concentration >0.155 ng/ml can serve as a predictor for the presence of hemodynamically significant CA stenosis in IHD patients (sensitivity 96.7%; specificity 70%), whereas a LRP6 concentration >12.94 ng/ml can predict the development of non-obstructive CA disease (sensitivity 76.7%; specificity 65%).

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冠状动脉疾病患者各种冠状动脉病变形成过程中的 WNT 信号级联蛋白和 LRP6。

目的：评估缺血性心脏病（IHD）以及阻塞性和非阻塞性冠状动脉（CA）疾病患者体内WNT1、WNT3a和LRP6的浓度：这项横断面观察性研究纳入了 50 名 IHD 患者（经冠状动脉造影证实，CAG），其中 25 名（50%）为男性，平均年龄（64.9±8.1）岁；20 名患者患有非阻塞性 CA 病（狭窄 <50%），30 名患者患有血流动力学意义上的狭窄。对所有患者的 WNT1、WNT3a 和 LRP6 的浓度进行了测量：IHD和阻塞性CA疾病患者的WNT1和WNT3a蛋白浓度明显更高（p <0.001），而非阻塞性CA疾病组的LRP6浓度更高（p = 0.016）。对阻塞性 CA 疾病组的数据分析显示，WNT1 和 LRP6 之间存在中度相关性（ρ=0.374；p=0.042）。对各组 CA 疾病患者进行的相关性分析显示，WNT1 的浓度与尿酸之间存在中度相关性（ρ=0.416；p=0.007）。回归分析表明，发生心肌梗死的危险因素，如体重指数增加、年龄、吸烟、血脂异常和高血压，对心肌梗死患者的 CA 疾病类型没有显著影响。根据ROC分析，WNT3a浓度高于0.155纳克/毫升和LRP6浓度低于12.94纳克/毫升可预测IHD的阻塞型：结论：患有非阻塞性CA疾病的IHD患者LRP6的升高幅度最大，而患有阻塞性CA疾病的患者WNT级联蛋白WNT1和WNT3a的浓度明显更高。根据ROC分析，WNT3a浓度为0.155纳克/毫升时，可预测IHD患者是否存在血流动力学意义上的CA狭窄（灵敏度为96.7%；特异度为70%），而LRP6浓度为12.94纳克/毫升时，可预测非阻塞性CA疾病的发生（灵敏度为76.7%；特异度为65%）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Kardiologiya 医学-心血管系统

CiteScore

1.70

自引率

20.00%

发文量

审稿时长

3-8 weeks

期刊介绍： “Kardiologiya” (Cardiology) is a monthly scientific, peer-reviewed journal committed to both basic cardiovascular medicine and practical aspects of cardiology. As the leader in its field, “Kardiologiya” provides original coverage of recent progress in cardiovascular medicine. We publish state-of-the-art articles integrating clinical and research activities in the fields of basic cardiovascular science and clinical cardiology, with a focus on emerging issues in cardiovascular disease. Our target audience spans a diversity of health care professionals and medical researchers working in cardiovascular medicine and related fields. The principal language of the Journal is Russian, an additional language – English (title, authors’ information, abstract, keywords). “Kardiologiya” is a peer-reviewed scientific journal. All articles are reviewed by scientists, who gained high international prestige in cardiovascular science and clinical cardiology. The Journal is currently cited and indexed in major Abstracting & Indexing databases: Web of Science, Medline and Scopus. The Journal''s primary objectives Contribute to raising the professional level of medical researchers, physicians and academic teachers. Present the results of current research and clinical observations, explore the effectiveness of drug and non-drug treatments of heart disease, inform about new diagnostic techniques; discuss current trends and new advancements in clinical cardiology, contribute to continuing medical education, inform readers about results of Russian and international scientific forums; Further improve the general quality of reviewing and editing of manuscripts submitted for publication; Provide the widest possible dissemination of the published articles, among the global scientific community; Extend distribution and indexing of scientific publications in major Abstracting & Indexing databases.