Heewon Cho, Na-Kyeong Hong, Insung Yong, Haw-Young Kwon, Nam-Young Kang, Larissa Miasiro Ciaramicoli, Pilnam Kim and Young-Tae Chang
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引用次数: 0
Abstract
Advanced glycation end products (AGEs) play a pivotal role in the aging process, regarded as a hallmark of aging. Despite their significance, the absence of adequate monitoring tools has hindered the exploration of the relationship between AGEs and aging. Here, we present a novel AGE-selective probe, AGO, for the first time. AGO exhibited superior sensitivity in detecting AGEs compared to the conventional method of measuring autofluorescence from AGEs. Furthermore, we validated AGO's ability to detect AGEs based on kinetics, demonstrating a preference for ribose-derived AGEs. Lastly, AGO effectively visualized glycation products in a collagen-based mimicking model of glycation. We anticipate that this study will enhance the molecular tool sets available for comprehending the physiological processes of AGEs during aging.
高级糖化终产物(AGEs)在衰老过程中起着举足轻重的作用,被认为是衰老的标志。尽管其意义重大,但由于缺乏适当的监测工具,阻碍了对 AGEs 与衰老之间关系的探索。在这里,我们首次提出了一种新型 AGE 选择性探针 AGO。与测量 AGEs 自发荧光的传统方法相比,AGO 在检测 AGEs 方面表现出更高的灵敏度。此外,我们还根据动力学验证了 AGO 检测 AGE 的能力,证明了它对核糖衍生 AGE 的偏好。最后,在基于胶原蛋白的糖化模拟模型中,AGO 能有效地观察糖化产物。我们预计这项研究将增强现有的分子工具集,以了解 AGEs 在衰老过程中的生理过程。
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices