Zongze Duan, Guizhi Dong, Hai Yang, Zhengwei Yan, Simin Liu, Yuanchen Dong and Zhiyong Zhao
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引用次数: 0
Abstract
DNA hydrogels have been demonstrated with the advantages of good stability, easy modification, and extraordinary biocompatibility, which enables their great application prospects in biosensing, tissue engineering, and biomedicine. Based on the host–guest recognition properties of cucurbit[8]uril (CB[8]), we proposed a general method for constructing functional supramolecular DNA nanogels. Guest molecules have been conjugated into the DNA building units, which could be further crosslinked with CB[8] to construct supramolecular DNA nanogels. At the same time, the aptamer has also been modified into the hydrogel network to achieve cell targeting. These supramolecular DNA nanogels have been demonstrated with a controllable size and multiple stimuli responses, in addition to the excellent biocompatibility, stability and good targeting drug transport ability. Such a host–guest based strategy will provide a molecular library as a “toolbox” for the functionalization of DNA nanogels.
DNA水凝胶具有稳定性好、易修饰、生物相容性强等优点,在生物传感、组织工程和生物医学等领域具有广阔的应用前景。基于葫芦[8]脲(CB[8])的主客体识别特性,我们提出了一种构建功能性超分子 DNA 纳米凝胶的通用方法。客体分子被连接到 DNA 构建单元中,然后与 CB[8] 进一步交联,从而构建超分子 DNA 纳米凝胶。同时,水凝胶网络中还修饰了适配体,以实现细胞靶向。这些超分子 DNA 纳米凝胶不仅具有良好的生物相容性、稳定性和药物靶向转运能力,还具有尺寸可控、多种刺激响应等特点。这种基于主客体的策略将为 DNA 纳米凝胶的功能化提供一个分子库作为 "工具箱"。
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices