Exploring the impact of N4-acetylcytidine modification in RNA on non-neoplastic disease: unveiling its role in pathogenesis and therapeutic opportunities.

IF 2.5 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Briefings in Functional Genomics Pub Date : 2025-01-15 DOI:10.1093/bfgp/elae020

Keyu Wan, Tiantian Nie, Wenhao Ouyang, Yunjing Xiong, Jing Bian, Ying Huang, Li Ling, Zhenjun Huang, Xianhua Zhu

引用次数: 0

Abstract

RNA modifications include not only methylation modifications, such as m6A, but also acetylation modifications, which constitute a complex interaction involving "writers," "readers," and "erasers" that play crucial roles in growth, genetics, and disease. N4-acetylcytidine (ac4C) is an ancient and highly conserved RNA modification that plays a profound role in the pathogenesis of a wide range of diseases. This review provides insights into the functional impact of ac4C modifications in disease and introduces new perspectives for disease treatment. These studies provide important insights into the biological functions of post-transcriptional RNA modifications and their potential roles in disease mechanisms, offering new perspectives and strategies for disease treatment.

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探索 RNA 中 N4-乙酰胞嘧啶修饰对非肿瘤性疾病的影响：揭示其在发病机制中的作用和治疗机会。

RNA 修饰不仅包括甲基化修饰（如 m6A），还包括乙酰化修饰，它们构成了一种复杂的相互作用，涉及 "写者"、"读者 "和 "擦除者"，在生长、遗传和疾病中发挥着至关重要的作用。N4-乙酰胞苷（ac4C）是一种古老而高度保守的 RNA 修饰，在多种疾病的发病机制中发挥着深远的作用。本综述深入探讨了 ac4C 修饰在疾病中的功能性影响，并为疾病治疗提供了新的视角。这些研究为了解转录后 RNA 修饰的生物学功能及其在疾病机制中的潜在作用提供了重要见解，为疾病治疗提供了新的视角和策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Briefings in Functional Genomics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-GENETICS & HEREDITY

CiteScore

6.30

自引率

2.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Briefings in Functional Genomics publishes high quality peer reviewed articles that focus on the use, development or exploitation of genomic approaches, and their application to all areas of biological research. As well as exploring thematic areas where these techniques and protocols are being used, articles review the impact that these approaches have had, or are likely to have, on their field. Subjects covered by the Journal include but are not restricted to: the identification and functional characterisation of coding and non-coding features in genomes, microarray technologies, gene expression profiling, next generation sequencing, pharmacogenomics, phenomics, SNP technologies, transgenic systems, mutation screens and genotyping. Articles range in scope and depth from the introductory level to specific details of protocols and analyses, encompassing bacterial, fungal, plant, animal and human data. The editorial board welcome the submission of review articles for publication. Essential criteria for the publication of papers is that they do not contain primary data, and that they are high quality, clearly written review articles which provide a balanced, highly informative and up to date perspective to researchers in the field of functional genomics.