Elucidating the Immune Microenvironment and Therapeutic Targets in Nasopharyngeal Carcinoma through Bioinformatics

IF 2.1 4区 医学 Q3 PHARMACOLOGY & PHARMACY Journal of Clinical Pharmacy and Therapeutics Pub Date : 2024-06-05 DOI:10.1155/2024/4239046
Shasha He, Yongbo Zheng
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Abstract

Background. Nasopharyngeal carcinoma (NPC), prevalent in East Asia and associated with EBV infection, poses unique challenges due to its complex immunological interactions. This study aims to dissect the molecular and immune mechanisms of NPC, providing a pathway to novel treatments. Methods. Through bioinformatics, we analyzed gene expression and immune cell infiltration in NPC tissues. Differential gene expression profiling, single-cell RNA sequencing, and gene set variation analysis (GSVA) were performed to understand the immune landscape and identify EBV-related molecular changes. Results. The differential gene expression analysis highlighted a diverse immune cell composition, suggesting an intricate immune evasion landscape. GSVA pinpointed pathways linked to tumor immunity and EBV pathogenesis. Notably, the expression of immune checkpoints, such as PD-L1, was significantly associated with NPC, offering a potential target for immunotherapy. Conclusions. Our findings underscore the potential of immunotherapeutic approaches in NPC, particularly those modulating the PD-1/PD-L1 axis. The integration of bioinformatics and immunology in NPC research provides a foundation for personalized medicine and warrants further exploration into combination therapies to enhance treatment efficacy.

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通过生物信息学阐明鼻咽癌的免疫微环境和治疗靶点
背景。鼻咽癌(NPC)流行于东亚地区,与EB病毒感染有关,因其复杂的免疫相互作用而构成了独特的挑战。本研究旨在剖析鼻咽癌的分子和免疫机制,为新型治疗提供途径。研究方法通过生物信息学,我们分析了鼻咽癌组织中的基因表达和免疫细胞浸润。我们进行了差异基因表达谱分析、单细胞 RNA 测序和基因组变异分析 (GSVA),以了解免疫状况并确定与 EBV 相关的分子变化。结果。差异基因表达分析凸显了免疫细胞组成的多样性,表明存在错综复杂的免疫逃避格局。GSVA 确定了与肿瘤免疫和 EBV 发病机制相关的通路。值得注意的是,免疫检查点(如 PD-L1)的表达与鼻咽癌密切相关,为免疫疗法提供了潜在靶点。结论我们的发现强调了免疫治疗方法在鼻咽癌中的潜力,尤其是那些调节 PD-1/PD-L1 轴的方法。在鼻咽癌研究中整合生物信息学和免疫学为个性化医疗奠定了基础,值得进一步探索联合疗法以提高疗效。
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来源期刊
CiteScore
4.10
自引率
5.00%
发文量
226
审稿时长
6 months
期刊介绍: The Journal of Clinical Pharmacy and Therapeutics provides a forum for clinicians, pharmacists and pharmacologists to explore and report on issues of common interest. Reports and commentaries on current issues in medical and pharmaceutical practice are encouraged. Papers on evidence-based clinical practice and multidisciplinary collaborative work are particularly welcome. Regular sections in the journal include: editorials, commentaries, reviews (including systematic overviews and meta-analyses), original research and reports, and book reviews. Its scope embraces all aspects of clinical drug development and therapeutics, including: Rational therapeutics Evidence-based practice Safety, cost-effectiveness and clinical efficacy of drugs Drug interactions Clinical impact of drug formulations Pharmacogenetics Personalised, stratified and translational medicine Clinical pharmacokinetics.
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