{"title":"Nickel(II)-Catalyzed Hydrocarbamoylation of Alkynes with Formamides towards Unsaturated Amides","authors":"Tiangui Li, Shiyang Wang, Zongxiang Xia, Jinbo Zhao, Dongyue Zhang, Yuanqi Wu, Yu Liu","doi":"10.1002/hlca.202400020","DOIUrl":null,"url":null,"abstract":"<p>Ni-catalyzed activation of C(sp<sup>2</sup>)−H bond remains an elusive challenge. Herein, we realized a Ni-catalyzed selective activation of C(sp<sup>2</sup>)−H bond of formamides, which underwent addition reaction with internal alkynes to provide α,β-unsaturated amide compounds in high yields. The protocol was featured by the cheap and nontoxic catalyst system. Preliminary mechanistic studies shed light on the reaction pathways.</p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":"107 8","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Helvetica Chimica Acta","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hlca.202400020","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Ni-catalyzed activation of C(sp2)−H bond remains an elusive challenge. Herein, we realized a Ni-catalyzed selective activation of C(sp2)−H bond of formamides, which underwent addition reaction with internal alkynes to provide α,β-unsaturated amide compounds in high yields. The protocol was featured by the cheap and nontoxic catalyst system. Preliminary mechanistic studies shed light on the reaction pathways.
期刊介绍：
Helvetica Chimica Acta, founded by the Swiss Chemical Society in 1917, is a monthly multidisciplinary journal dedicated to the dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences, where molecular aspects are key to the findings. Helvetica Chimica Acta is committed to the publication of original, high quality papers at the frontier of scientific research. All contributions will be peer reviewed with the highest possible standards and published within 3 months of receipt, with no restriction on the length of the papers and in full color.
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