Dewei Zhao, Liangliang Cheng, Faqiang Lu, Xiuzhi Zhang, Jiawei Ying, Xiaowei Wei, Fang Cao, Chunxiao Ran, Guoshuang Zheng, Ge Liu, Pinqiao Yi, Haiyao Wang, Liqun Song, Bin Wu, Lingpeng Liu, Lu Li, Xiaohu Wang, Junlei Li
{"title":"Design, fabrication, and clinical characterization of additively manufactured tantalum hip joint prosthesis","authors":"Dewei Zhao, Liangliang Cheng, Faqiang Lu, Xiuzhi Zhang, Jiawei Ying, Xiaowei Wei, Fang Cao, Chunxiao Ran, Guoshuang Zheng, Ge Liu, Pinqiao Yi, Haiyao Wang, Liqun Song, Bin Wu, Lingpeng Liu, Lu Li, Xiaohu Wang, Junlei Li","doi":"10.1093/rb/rbae057","DOIUrl":null,"url":null,"abstract":"\n The joint prosthesis plays a vital role in the outcome of total hip arthroplasty. The key factors that determine the performance of joint prostheses are the materials used and the structural design of the prosthesis. This study aimed to fabricate a porous tantalum (Ta) hip prosthesis using selective laser melting (SLM) technology. The feasibility of SLM Ta use in hip prosthesis was verified by studying its chemical composition, metallographic structure, and mechanical properties. In vitro experiments proved that SLM Ta exhibited better biological activities in promoting osteogenesis and inhibiting inflammation than SLM Ti6Al4V. Then, the topological optimization design of the femoral stem of the SLM Ta hip prosthesis was carried out by finite element simulation, and the fatigue performance of the optimized prosthesis was tested to verify the biomechanical safety of the prosthesis. A porous Ta acetabulum cup was also designed and fabricated using SLM. Its mechanical properties were then studied. Finally, clinical trials were conducted to verify the clinical efficacy of the SLM Ta hip prosthesis. The porous structure could reduce the weight of the prosthesis and stress shielding and avoid bone resorption around the prosthesis. In addition, anti-infection drugs can also be loaded into the pores for infection treatment. The acetabular cup can be custom-designed based on the severity of bone loss on the acetabular side, and the integrated acetabular cup can repair the acetabular bone defect while achieving the function of the acetabular cup.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":5.6000,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Regenerative Biomaterials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1093/rb/rbae057","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
The joint prosthesis plays a vital role in the outcome of total hip arthroplasty. The key factors that determine the performance of joint prostheses are the materials used and the structural design of the prosthesis. This study aimed to fabricate a porous tantalum (Ta) hip prosthesis using selective laser melting (SLM) technology. The feasibility of SLM Ta use in hip prosthesis was verified by studying its chemical composition, metallographic structure, and mechanical properties. In vitro experiments proved that SLM Ta exhibited better biological activities in promoting osteogenesis and inhibiting inflammation than SLM Ti6Al4V. Then, the topological optimization design of the femoral stem of the SLM Ta hip prosthesis was carried out by finite element simulation, and the fatigue performance of the optimized prosthesis was tested to verify the biomechanical safety of the prosthesis. A porous Ta acetabulum cup was also designed and fabricated using SLM. Its mechanical properties were then studied. Finally, clinical trials were conducted to verify the clinical efficacy of the SLM Ta hip prosthesis. The porous structure could reduce the weight of the prosthesis and stress shielding and avoid bone resorption around the prosthesis. In addition, anti-infection drugs can also be loaded into the pores for infection treatment. The acetabular cup can be custom-designed based on the severity of bone loss on the acetabular side, and the integrated acetabular cup can repair the acetabular bone defect while achieving the function of the acetabular cup.
关节假体对全髋关节置换术的效果起着至关重要的作用。决定关节假体性能的关键因素是假体使用的材料和结构设计。本研究旨在利用选择性激光熔化(SLM)技术制造多孔钽(Ta)髋关节假体。通过研究钽的化学成分、金相结构和机械性能,验证了将 SLM 技术用于髋关节假体的可行性。体外实验证明,与 SLM Ti6Al4V 相比,SLM Ta 在促进成骨和抑制炎症方面表现出更好的生物活性。随后,通过有限元模拟对 SLM Ta 髋关节假体的股骨柄进行了拓扑优化设计,并对优化后的假体进行了疲劳性能测试,以验证假体的生物力学安全性。此外,还使用 SLM 设计并制造了多孔 Ta 髋臼杯。然后对其机械性能进行了研究。最后,进行了临床试验,以验证 SLM Ta 髋关节假体的临床疗效。多孔结构可减轻假体的重量和应力屏蔽,避免假体周围的骨吸收。此外,抗感染药物也可装入孔中,用于治疗感染。髋臼杯可以根据髋臼一侧骨质流失的严重程度进行定制设计,集成髋臼杯可以修复髋臼骨缺损,同时实现髋臼杯的功能。
期刊介绍:
Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.