Intelligent Miniplatform for On-Site Monitoring of Water Samples and Pharmaceutical Production of Ointments Based on Betamethasone and Gentamicin as Active Pharmaceutical Ingredients

Abstract

Betamethasone and gentamicin combination is commonly used in various dermatological conditions. In addition to the topical dosage forms in which this combination can be found, it can also accidentally end up in surface water following removal by washing. For this reason, a disposable miniplatform was constructed by modifying a boron-doped diamond screen printed electrode with calix[4]arene-25,26,27,28-tetrol. Wide linear ranges and low limits of quantification (LOQ) were achieved for both analytes: 1.0 × 10−16 − 1.0 × 10−2 mol L‒1 and a LOQ of 1.0 × 10−16 mol L‒1 for betamethasone, and 1.0 × 10−17 − 1.0 × 10−2 mol L‒1 and a LOQ of 1.0 × 10−17 mol L‒1 for gentamicin. The platform was tested on real samples, obtaining recovery values close to 100% and relative standard deviation values below 0.03%. Additionally, a comparison is provided between the proposed approach and existing electrochemical sensors to emphasize the achieved results.