Visible-light-catalyzed Synthesis of Amino Alcohols from N,N-dimethylaniline and Aryl Aldehyde

Abstract

Herein, we describe a direct radical addition reaction of aryl aldehyde and N, N-dimethylaniline using iridium complex as photocatalysts to form amino alcohols under mild conditions, which exhibit an excellent convenient and sustainable methodology. The reaction could be easily scale up through continuous flow with high yield. Mechanism studies with the assistance of DFT calculations indicated such a reaction undertaking a radical pathway.