{"title":"Visible-light-catalyzed Synthesis of Amino Alcohols from N,N-dimethylaniline and Aryl Aldehyde","authors":"Jia-Hui Jin, Yi-Jian Ma, Yu-Yun Yin, Fu-Gang Zhao, Cheng-Shuo Shen, Cheng-Miao Xu, Yong-Miao Shen","doi":"10.1093/chemle/upae112","DOIUrl":null,"url":null,"abstract":"\n Herein, we describe a direct radical addition reaction of aryl aldehyde and N, N-dimethylaniline using iridium complex as photocatalysts to form amino alcohols under mild conditions, which exhibit an excellent convenient and sustainable methodology. The reaction could be easily scale up through continuous flow with high yield. Mechanism studies with the assistance of DFT calculations indicated such a reaction undertaking a radical pathway.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"35 32","pages":""},"PeriodicalIF":17.7000,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1093/chemle/upae112","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
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Abstract
Herein, we describe a direct radical addition reaction of aryl aldehyde and N, N-dimethylaniline using iridium complex as photocatalysts to form amino alcohols under mild conditions, which exhibit an excellent convenient and sustainable methodology. The reaction could be easily scale up through continuous flow with high yield. Mechanism studies with the assistance of DFT calculations indicated such a reaction undertaking a radical pathway.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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