Administering Fluralaner in Drinking Water for Treatment of Dermanyssus gallinae Infestation in Hy-Line W80 Laying Hens

IF 1.8 4区 医学 Q3 PHARMACOLOGY & PHARMACY Iranian Journal of Pharmaceutical Research Pub Date : 2024-06-02 DOI:10.5812/ijpr-145526
MohammadReza Raeisi, Abdolkarim Zamani Moghaddam, Seyyed sattar Tohidifar, Maryam Malekan
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Abstract

Background: Poultry red mites, or Dermanyssus gallinae, pose a threat to the welfare and productivity of laying hens. Moreover, the increasing resistance of these mites to conventional miticides highlights the urgent need for alternative treatment options. There are also documented cases of poultry red mite infestations in humans. Objectives: The primary objective of this study was to evaluate the efficacy of fluralaner against Dermanyssus gallinae infestation in hens. Methods: Fluralaner was selected as a novel treatment for poultry red mite due to its effectiveness and safety profile. The presence of live mites in the drinking water tank served as the indicator of infestation. Live mites were counted on nine occasions throughout the study. Fluralaner was administered at three doses of 0.5 mg/kg in drinking water with a seven-day interval between each dose. The efficacy of fluralaner was assessed, with an efficacy percentage exceeding 90% considered indicative of antiparasitic efficacy. Results: The overall efficacy of Fluralaner in the current study exceeded 90% by day 5 and reached 100% by day 17. Conclusions: This study demonstrates that fluralaner is an effective alternative treatment, achieving efficacy rates exceeding 90% against poultry red mite infestation in laying hens.
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在饮用水中添加氟乐灵,用于治疗 Hy-Line W80 产蛋鸡的五倍子虫害
背景:家禽红螨(Dermanyssus gallinae)对蛋鸡的福利和生产力构成威胁。此外,这些螨虫对传统杀螨剂的抗药性越来越强,这凸显了对替代治疗方案的迫切需求。据记载,人类也曾感染过家禽红螨。研究目的本研究的主要目的是评估氟乐灵对母鸡Dermanyssus gallinae虫害的疗效。方法:选择氟拉尼醇作为一种杀虫剂:氟乐灵因其有效性和安全性被选为家禽红螨的新型治疗方法。饮水槽中出现的活螨是虫害的指标。在整个研究过程中,对活螨进行了九次计数。氟乐灵在饮用水中的剂量为 0.5 毫克/千克,共三次,每次间隔七天。对氟拉那尔的药效进行评估,药效百分比超过 90% 即表明具有抗寄生虫药效。结果在本次研究中,氟拉那尔的总体疗效在第5天时超过了90%,在第17天时达到了100%。结论:本研究表明,氟拉那尔是一种有效的替代治疗方法,对蛋鸡的家禽红螨感染有效率超过 90%。
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来源期刊
CiteScore
3.40
自引率
6.20%
发文量
52
审稿时长
2 months
期刊介绍: The Iranian Journal of Pharmaceutical Research (IJPR) is a peer-reviewed multi-disciplinary pharmaceutical publication, scheduled to appear quarterly and serve as a means for scientific information exchange in the international pharmaceutical forum. Specific scientific topics of interest to the journal include, but are not limited to: pharmaceutics, industrial pharmacy, pharmacognosy, toxicology, medicinal chemistry, novel analytical methods for drug characterization, computational and modeling approaches to drug design, bio-medical experience, clinical investigation, rational drug prescribing, pharmacoeconomics, biotechnology, nanotechnology, biopharmaceutics and physical pharmacy.
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