Skin-like breathable wound dressings with antimicrobial and hemostatic properties

IF 5.4 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY GIANT Pub Date : 2024-06-03 DOI:10.1016/j.giant.2024.100300

Hanbai Wu , Chuanwei Zhi , Yuhan Chen , Xiong Zhou , Cong Wang , Raymond H.W. Lam , Tingwu Qin , Guibing Fu , Zhu Xiong , Kaisong Huang , Jia-Horng Lin , Shuo Shi , Jinlian Hu

{"title":"Skin-like breathable wound dressings with antimicrobial and hemostatic properties","authors":"Hanbai Wu , Chuanwei Zhi , Yuhan Chen , Xiong Zhou , Cong Wang , Raymond H.W. Lam , Tingwu Qin , Guibing Fu , Zhu Xiong , Kaisong Huang , Jia-Horng Lin , Shuo Shi , Jinlian Hu","doi":"10.1016/j.giant.2024.100300","DOIUrl":null,"url":null,"abstract":"<div><p>Wound healing requires a contamination-free, sterile, and breathable environment. However, to develop an ideal wound dressing with all these functionalities simultaneously poses significant challenges. In this study, we designed a wound dressing that mimics the structure of skin with good breathability and protective functions. The wound dressing consists of a hydrophilic Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB) membrane coated with zinc oxide nanoparticles and a hydrophobic polyvinylidene fluoride (PVDF) membrane. Meanwhile, plasma treatment was also utilized to bond the two layers, resulting in an enhancement of 60 % in mechanical properties. The crosslinked fibrous membranes exhibited uniform stress distribution when stretching. Due to the unique structures of the wound dressing, it demonstrates wound exudate management, antibacterial functions, and hemostatic properties. The hydrophobic layer guided wound exudate towards the hydrophilic layer and the zinc oxide nanoparticles acted as a barrier against external bacteria and released zinc ions to inhibit bacterial growth in the exudate. Moreover, the water vapor transmission rate (WVTR) was measured to be over 86.55 kg/m<sup>2</sup>/day, the hemolysis rate was 2.38 %, and an impressive 81.98 % healing rate was recorded during in vitro wound healing. This skin-mimicking wound dressing shows great potential as a promising solution for the therapy of chronic wounds and infections.</p></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":"19 ","pages":"Article 100300"},"PeriodicalIF":5.4000,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266654252400064X/pdfft?md5=aca2c6568e1d3af723d9eaa731161789&pid=1-s2.0-S266654252400064X-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"GIANT","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S266654252400064X","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Wound healing requires a contamination-free, sterile, and breathable environment. However, to develop an ideal wound dressing with all these functionalities simultaneously poses significant challenges. In this study, we designed a wound dressing that mimics the structure of skin with good breathability and protective functions. The wound dressing consists of a hydrophilic Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB) membrane coated with zinc oxide nanoparticles and a hydrophobic polyvinylidene fluoride (PVDF) membrane. Meanwhile, plasma treatment was also utilized to bond the two layers, resulting in an enhancement of 60 % in mechanical properties. The crosslinked fibrous membranes exhibited uniform stress distribution when stretching. Due to the unique structures of the wound dressing, it demonstrates wound exudate management, antibacterial functions, and hemostatic properties. The hydrophobic layer guided wound exudate towards the hydrophilic layer and the zinc oxide nanoparticles acted as a barrier against external bacteria and released zinc ions to inhibit bacterial growth in the exudate. Moreover, the water vapor transmission rate (WVTR) was measured to be over 86.55 kg/m²/day, the hemolysis rate was 2.38 %, and an impressive 81.98 % healing rate was recorded during in vitro wound healing. This skin-mimicking wound dressing shows great potential as a promising solution for the therapy of chronic wounds and infections.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

具有抗菌和止血功能的类肤透气伤口敷料

伤口愈合需要一个无污染、无菌和透气的环境。然而，要开发一种同时具备所有这些功能的理想伤口敷料却面临着巨大的挑战。在这项研究中，我们设计了一种模仿皮肤结构、具有良好透气性和保护功能的伤口敷料。该伤口敷料由亲水性聚（3-羟基丁酸-4-羟基丁酸）（P34HB）膜和疏水性聚偏二氟乙烯（PVDF）膜组成，前者涂有纳米氧化锌颗粒。同时，还利用等离子处理将两层膜粘合在一起，从而使机械性能提高了 60%。交联纤维膜在拉伸时表现出均匀的应力分布。由于伤口敷料的独特结构，它具有伤口渗液管理、抗菌和止血功能。疏水层能引导伤口渗出物流向亲水层，而纳米氧化锌颗粒则能阻挡外部细菌，并释放锌离子抑制渗出物中的细菌生长。此外，经测量，水蒸气透过率（WVTR）超过 86.55 千克/平方米/天，溶血率为 2.38%，体外伤口愈合率高达 81.98%。这种仿皮伤口敷料显示出巨大的潜力，是治疗慢性伤口和感染的理想解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

GIANT Multiple-

CiteScore

8.50

自引率

8.60%

发文量

审稿时长

42 days

期刊介绍： Giant is an interdisciplinary title focusing on fundamental and applied macromolecular science spanning all chemistry, physics, biology, and materials aspects of the field in the broadest sense. Key areas covered include macromolecular chemistry, supramolecular assembly, multiscale and multifunctional materials, organic-inorganic hybrid materials, biophysics, biomimetics and surface science. Core topics range from developments in synthesis, characterisation and assembly towards creating uniformly sized precision macromolecules with tailored properties, to the design and assembly of nanostructured materials in multiple dimensions, and further to the study of smart or living designer materials with tuneable multiscale properties.