MICB Genetic Variants and Its Protein Soluble Level Are Associated with the Risk of Chronic GvHD and CMV Infection after Allogeneic HSCT.

IF 2.9 4区 医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2024-06-07 eCollection Date: 2024-01-01 DOI:10.2478/aite-2024-0012
Jagoda Siemaszko, Marta Dratwa, Agnieszka Szeremet, Maciej Majcherek, Anna Czyż, Małgorzata Sobczyk-Kruszelnicka, Wojciech Fidyk, Iwona Solarska, Barbara Nasiłowska-Adamska, Patrycja Skowrońska, Maria Bieniaszewska, Agnieszka Tomaszewska, Grzegorz W Basak, Sebastian Giebel, Tomasz Wróbel, Katarzyna Bogunia-Kubik
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Abstract

The aim of the present study was to determine the associations between the MICB genetic variability and the expression and the risk of development of post-transplant complications after allogeneic hematopoietic stem cell transplantation (HSCT). HSCT recipients and their donors were genotyped for two MICB polymorphisms (rs1065075, rs3828903). Moreover, the expression of a soluble form of MICB was determined in the recipients' serum samples after transplantation using the Luminex assay. Our results revealed a favorable role of the MICB rs1065075 G allele. Recipients with donors carrying this genetic variant were less prone to developing chronic graft-versus-host disease (cGvHD) when compared to recipients without any symptoms of this disease (41.41% vs. 65.38%, p = 0.046). Moreover, the MICB rs1065075 G allele was associated with a lower incidence of cytomegalovirus (CMV) reactivation, both as a donor (p = 0.015) and as a recipient allele (p = 0.039). The MICB rs1065075 G variant was also found to be associated with decreased serum soluble MICB (sMICB) levels, whereas serum sMICB levels were significantly higher in recipients diagnosed with CMV infection (p = 0.0386) and cGvHD (p = 0.0008) compared to recipients without those complications. A protective role of the G allele was also observed for the rs3828903 polymorphism, as it was more frequently detected among donors of recipients without cGvHD (89.90% vs. 69.23%; p = 0.013). MICB genetic variants, as well as serum levels of sMICB, may serve as prognostic factors for the risk of developing cGvHD and CMV infection after allogeneic HSCT.

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MICB基因变异及其蛋白可溶性水平与异基因造血干细胞移植后发生慢性GvHD和CMV感染的风险有关。
本研究旨在确定异基因造血干细胞移植(HSCT)后 MICB 基因变异与移植后并发症的表达和发生风险之间的关系。对造血干细胞移植受者及其供者进行了两个MICB多态性(rs1065075和rs3828903)的基因分型。此外,还使用 Luminex 检测法测定了移植后受者血清样本中可溶性 MICB 的表达。我们的研究结果表明,MICB rs1065075 G 等位基因起着有利的作用。与没有任何慢性移植物抗宿主病(cGvHD)症状的受者相比,供体携带该基因变异的受者更不容易患上该病(41.41% vs. 65.38%,p = 0.046)。此外,MICB rs1065075 G 等位基因与巨细胞病毒(CMV)再激活的发生率较低有关,无论是作为供体(p = 0.015)还是作为受体等位基因(p = 0.039)。研究还发现,MICB rs1065075 G 变体与血清可溶性 MICB(sMICB)水平下降有关,而与无上述并发症的受者相比,确诊为 CMV 感染(p = 0.0386)和 cGvHD(p = 0.0008)的受者血清 sMICB 水平明显更高。在 rs3828903 多态性中还观察到 G 等位基因的保护作用,因为在无 cGvHD 的受者的供体中更常检测到 G 等位基因(89.90% 对 69.23%;p = 0.013)。MICB 基因变异和血清中的 sMICB 水平可作为异基因造血干细胞移植后罹患 cGvHD 和 CMV 感染风险的预后因素。
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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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