Genomic analysis uncovers that cold-inducible RNA binding protein is associated with estrogen receptor in breast cancer.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-08-01 Epub Date: 2024-06-07 DOI:10.1007/s13258-024-01530-w

Eun-Yeung Gong, Dana Jung, Hyunmin Woo, Jinhoo Song, Eunjeong Choi, Seo-Gyeong Jo, Seong-Il Eyun, Seokho Kim, Yun-Yong Park

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Abstract

Background: RNA-binding proteins (RBPs) perform various biological functions in humans and are associated with several diseases, including cancer. Therefore, RBPs have emerged as novel therapeutic targets. Although recent investigations have shown that RBPs have crucial functions in breast cancer (BC), detailed research is underway to determine the RBPs that are closely related to cancers.

Objective: To provide an insight into estrogen receptor (ER) regulation by cold-inducible RNA binding protein (CIRBP) as a novel therapeutic target.

Results: By analyzing the genomic data, we identified a potential RBP in BC. We found that CIRBP is highly correlated with ER function and influences clinical outcomes, such as patient survival and endocrine therapy responsiveness. In addition, CIRBP influences the proliferation of BC cells by directly binding to ER-RNA.

Conclusion: Our results suggest that CIRBP is a novel upstream regulator of ER and that the interplay between CIRBP and ER may be associated with the clinical relevance of BC.

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基因组分析发现冷诱导 RNA 结合蛋白与乳腺癌中的雌激素受体有关。

背景：RNA 结合蛋白（RBPs）在人体中发挥着多种生物学功能，并与包括癌症在内的多种疾病相关。因此，RBPs 已成为新的治疗靶点。尽管最近的研究表明，RBPs 在乳腺癌（BC）中具有关键功能，但目前仍在进行详细研究，以确定与癌症密切相关的 RBPs：结果：通过分析基因组数据，研究人员发现冷诱导 RNA 结合蛋白（CIRBP）对雌激素受体（ER）的调控是一个新的治疗靶点：结果：通过分析基因组数据，我们发现了 BC 中潜在的 RBP。我们发现，CIRBP与ER功能高度相关，并影响临床结果，如患者生存率和内分泌治疗反应性。此外，CIRBP 通过直接与 ER-RNA 结合影响 BC 细胞的增殖：我们的研究结果表明，CIRBP是ER的一种新型上游调节因子，CIRBP与ER之间的相互作用可能与BC的临床相关性有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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